Abstract: FR-PO1022

Inter-Correlations between Psychosocial Pre Transplant Determinant of Post-Transplant Kidney Allograft Function

Session Information

Category: Transplantation

  • 1702 Transplantation: Clinical and Translational

Authors

  • Shah, Sujan P, University of Texas Medical Branch, Galveston, Texas, United States
  • Schreiber, Brittany Lauren, University of Texas Medical Branch, Galveston, Texas, United States
  • Espinoza, Flor, University of Texas Medical Branch, Galveston, Texas, United States
  • Gamilla-Crudo, Ann Kathleen N., University of Texas Medical Branch, Galveston, Texas, United States
  • Patankar, Rohan, University of Texas Medical Branch, Galveston, Texas, United States
  • Aleter, Omar A., University of Texas Medical Branch, Galveston, Texas, United States
  • Fischer, Wayne G, University of Texas Medical Branch, Galveston, Texas, United States
  • Mujtaba, Muhammad Ahmad, University of Texas Medical Branch, Galveston, Texas, United States
Background

Psychosocial factors are common in patients with advanced and end stage kidney disease and they may be associated with post kidney transplant outcomes. When these patients are referred for transplant evaluation psychosocial and nutrition history is an important component of evaluation however there is lack of data on post-transplant implication of these factors.
The aim of this study was to determine the correlations between pretransplant, nonclinical and psychosocial factors to post-transplant clinical outcomes .

Methods

We selected the following pre-transplant factors: gender, food stamp, marital relationship, insurer, education, Karnofsky score, history of depression,exercise, albumin level history of substance abuse, distance from transplant center.
The posttransplant clinical outcomes selected were quality of kidney allograft at 6 months expressed as serum creatinine.
The study involved retrospective analysis of 136 kidney transplant patients. There were 56 female patients and 75 male patients. We had 72 Hispanics (53%), 33 African Americans (24%), 22 Whites (16%), 9 Asians (7%). Patients age ranged from 25 years to 77 years.
We used nominal logistic regression analysis and multinominal logistic regression analysis to
identify the significant relationship between one dependent nominal variable and one or more continuous-level independent variables.
A p-value of ≤ 0.05 was considered significant.

Results

Factors associated with significantly better serum creatinine at 6 months included: Female gender (p 0.014), active pre listing clinic follow up (0.0001), compliance with dialysis (0.06), and serum albumin >3.5 gm/dl (0.007). Patient primary insurer, family support, mariatal status, exercise, food stamp status, history of depression, history of substance abuse, education level, race, distance from transplant center, and retransplant status was not found to be associated with 6 months serum creatinine.

Conclusion

Pretransplant psychosocial factors are associated with the post transplant kidney allograft function . This also shows the pre transplant psychosocial history is an integral but often ignored part of evaluation and should be stressed upon. More prospective trials are required to confirm our findings.