Abstract: TH-PO107

Crescentic Lesions and Renal Outcomes in IgA Nephropathy: Validation of the Updated Oxford Classification in Brazilian Patients

Session Information

Category: Glomerular

  • 1004 Clinical/Diagnostic Renal Pathology and Lab Medicine

Authors

  • Neves, Precil D, University of S?o Paulo, S?o Paulo, Brazil
  • Pinheiro, Rafaela B, University of São Paulo, São Paulo, Brazil
  • Dias, Cristiane B., University of Sao Paulo, Brazil, São Paulo, Brazil
  • Yu, Luis, University of Sao Paolo School of Medicine, Sao Paulo, Brazil
  • Testagrossa, Leonardo A., University of São Paulo, São Paulo, Brazil
  • Woronik, Viktoria, None, Salvador, Brazil
  • Jorge, Lectícia, University of São Paulo, São Paulo, Brazil
Background

Background: IgA Nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide. The Oxford Classification (OC) of IgAN has been recently updated and crescentic lesions were recognized as histological features related to worst renal outcomes.
Objectives: Evaluation of crescentic lesions impact in renal outcomes in IgAN patients and validation of the new Oxford Classification of IgAN (MEST-C) in brazilian patients.

Methods

Methods: Analysis of medical reports database and kidney biopsy of patients with diagnosis of IgAN. Kidney biopsy were classified according new OC (MEST-C). Composite outcome was doubling of baseline serum creatinine concentration or end stage kidney disease. We performed comparative analyses between groups with and without crescentic lesions in kidney biopsy.

Results

Results: In the following image we describe baseline clinical data and kidney biopsy features of patients with IgAN as well comparative analysis of groups with (C1/C2) and without (C0) crescentic lesions in kidney biopsy.

Conclusion

Conclusion: Crescentic lesions were associated with both worst renal function at biopsy and outcomes in brazilian patients. These data ratify previous findings in the literature.