Abstract: SA-PO894

Comparison of the Prevalence of Mineral and Bone Disorders in Elderly and Non-Elderly Dialysis Population

Session Information

  • Mineral Disease: CKD-Bone
    November 04, 2017 | Location: Hall H, Morial Convention Center
    Abstract Time: 10:00 AM - 10:00 AM

Category: Mineral Disease

  • 1203 Mineral Disease: CKD-Bone

Authors

  • Costa, Andre Falcao pedrosa, Federal University of Alagoas, Brazil, Maceió, Brazil
  • Teles de Farias Filho, Flavio, UNCISAL, Maceio,, ALAGOAS, Brazil
Background

Disorders in mineral and bone metabolism are common in patients with chronic kidney disease (CKD). These disturbs is a set of clinical-laboratory changes that cause negative effects on the various outcomes of chronic renal failure patients. International consensuses, like KDOQI and KDIGO were intended to assist the practitioner caring for adults and children with CKD stages 3-5, on chronic dialysis therapy, or with a kidney transplant. But there are no specific recommendations for analysis and management of elderly patients.

Methods

The study included a population of hemodialysis patients from a in-hospital service in the city of Maceió, Brazil. We performed a cross - sectional study of patients on hemodialysis for at least 3 months. We observed the socio-demographic, clinical data and the annual average of the laboratory analyzes. The data were then compared between Group 1 patients > 60 years and Group 2 patientes < 55 years.

Results

168 patients were evaluated, 41 of Group 1 and 147 of Group 2. Group 1: age 68.5 years (± 5.81); 68% men; diabetic nephropathy as the main underlying disease (51%); weakness as the most reported complaint (50%); PTH 183 ± 23.86 pg / ml; alkaline phosphatase 104 ± 9.07 U / L; serum calcium 9 ± 0.11 mg / dL; serum phosphorus 4.56 ± 0.13 mg / dl. Group 2: age 39.5 years (± 14.9); 54% men; hypertensive nephrosclerosis as the main underlying disease; PTH 368.20 ± 29.78pg/ml; alkaline phosphatase 148.60 UI ± 9.61; serum calcium: 8.93 ± 0.05 mg/dL; serum phosphorus: 5.51 ± 0.10 mg/dL. Group 1 exibited PTH and alkaline phosphatase values lower than Group 2, especially in females (p <0.0001). There were differences in serum phosphorus levels - being higher in Group 1 (p <0.001). The comparison between elderly women and men showed no siguinificative differences. It is inferred that sex is probably not a determining factor in the pattern of alterations in the parameters of mineral disorders but age was an independent factor in the profile of this population.

Conclusion

Differences in the pattern of prevalence of the main bone and mineral disorders among the elderly and non-elderly can be observed. Studies with a greater number of patients may corroborate the need to establish specific guidelines for the mineral and bone disorders of elderly patients with chronic kidney disease.