Abstract: FR-PO478

Urinary Orosomucoid Is Associated with Cardiovascular Risk Factors and Kidney Dysfunction: Cross-Sectional Data from the Tromsø Study

Session Information

Category: Chronic Kidney Disease (Non-Dialysis)

  • 303 CKD: Epidemiology, Outcomes - Cardiovascular

Authors

  • Andreassen, Runa Marie, Department of Internal Medicine, Helgelandssykehuset, Sandnessjøen, Sandnessjøen, Norway
  • Solbu, Marit D., Section of Nephrology, University Hospital of North Norway, Tromsø, Norway., Tromsø, Norway
Background

The acute phase protein orosomucoid is a component of the endothelial cell coat. It may be hypothesised that leakage of orosomucoid into the urine may be a more sensitive marker of a damaged filtration barrier than albuminuria. However, this has never been assessed in a general population. The aim of this cross-sectional study was to examine the univariate associations between urinary orosomucoid to creatinine ratio (UOCR), urinary albumin to creatinine ratio (UACR) and common cardiovascular (CV) risk factors, and to assess whether there is an independent association between eGFR and UOCR in a middle-aged cohort from the general population.

Methods

From the sixth wave of The Tromsø Study (2007/08) we included all participants who had measurements of urinary orosomucoid. Orosomucoid, albumin and creatinine were measured in three morning urinary specimens, and we used the median values from the three days for UACR and UOCR. The cohort was categorized according to some well known CV risk factors and the associations between UOCR, UACR, eGFR and risk factors were assessed by linear and logistic regressions analysis.

Results

A total of 3086 men and 4095 women were included; mean age was 63.5 (±9.2 SD) years. Mean eGFR was 88 (±14 SD) ml/min/1.73 m2. UOCR was significantly higher in men than in women and positively correlated with age.
UOCR was also higher in subjects with BMI ≥25 kg/m2 than BMI <25 kg/m2 median 0.48 (IQR 0.24, 1.13) g/g vs. 0.37 (0.21, 0.85) g/g; P<0.001), as well as in hypertensive compared to normotensive subjects 0.56 (0.27, 1.31) g/g vs. 0.35 (0.20, 0.77); P<0.001) and smokers compared to non-smokers 0.50 (0.24, 1.18) g/g vs 0.43 (0.23, 0.99) g/g; P=0.002.
UACR was positively associated with the same risk factors except BMI. In multivariable logistic regression analysis, both eGFR and UACR were independent risk factors for having UOCR above median (eGFR: odds ratio (OR) 0.83 (0.79-0,88) per 10 ml/min/1.73 m2, UACR: OR 2.05 (1.91-2.19)) per 0.5mg/mmol.

Conclusion

UOCR was positively associated with CV risk factors, and the association between eGFR and UOCR was independent of these factors and UACR. Our data indicate that increased UOCR may serve as a novel biomarker of atherosclerosis and kidney dysfunction, thereby supporting further research.

Funding

  • Government Support - Non-U.S.