Abstract: TH-PO996

Android Obesity and NT-ProBNP in Kidney Transplant Patients

Session Information

Category: Transplantation

  • 1702 Transplantation: Clinical and Translational

Author

  • Kaziuk, Magdalena Barbara, Jagiellonian University Medical College, Kraków, Poland
Background

Adipose tissue is a typical location for storage of water-insoluble toxins in a body. An excess of adipose tissue may be either systemic or local. According to a pattern of fat distribution in the body, we distinguish two types of obesity: android (visceral, abdominal) and gynoid (around bottom and tights, peripheral). The obesity increases a risk of the kidney failure and cardiovascular complications in a group of kidney transplant patients (KTx).
An attempt was made to evaluate a relationship between the amount of adipose tissue, obesity type, and NT- proBNP level in KTx patients.

Methods

The study covered 128 patients (60 women and 68 men, average age 49.5 ± 10.8 years) with a functioning renal transplant more than 3 months after the transplant. The amount of adipose tissue was determined using the bioelectrical impedance analysis (BIA) and anthropometric measurements, nutrition status and the obesity type were established by Waist to Height Ratio (WHtR) and Waist to Hip Ratio (WHR), the function of the transplanted kidney was evaluated by calculation of the estimated glomerular filtration rate (eGFR) using the MDRD formula, and their relation with the N-terminal pro-brain natriuretic peptide (NT- proBNP) was studied.

Results

In the study group, 22.7% of patients were classified as having a correct body weight, while 56.7% and 20.6% of participants had an android and gynoid type, respectively.
In the logistic regression analysis, an increase by 0.2% in a risk of abdominal obesity in KTx patients (OR=1.002 95% CI: 1.001–1.003; p< 0.001) was associated with an increase in NT- proBNP by 100 pg/ml. An increase in eGFR by 1ml/min/1,73m2 was associated with a reduction in the androidal obesity risk by 4.5% (OR= 0.955 95% CI: 0.923–0.984; p=0.005).
The higher the NT-proBNP value, the higher the percentage content of adipose tissue (Spearman rank correlation coefficient: 0.473; p<0.001) in KTx patients.

Conclusion

A large amount of adipose tissue, particularly in a case of androidal obesity, may be a predictor of kidney or cardiovascular system. Furthermore, high NT-proBNP levels may be associated with an increased risk of obesity in KTx patients; therefore, correct diet and pharmacological management, and physical activity adapted to the physical fitness level of a patient are necessary.