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Abstract: SA-PO738

Adherence to Mediterranean Diet Predicts the Presence of Left Ventricular Hypertrophy (LVH) and Patterns of LV Remodeling in Peritoneal Dialysis (PD) Patients

Session Information

  • Peritoneal Dialysis - II
    November 04, 2017 | Location: Hall H, Morial Convention Center
    Abstract Time: 10:00 AM - 10:00 AM

Category: Dialysis

  • 608 Peritoneal Dialysis

Authors

  • Bacharaki, Dimitra, ATTIKON UNIVERSITY HOSPITAL , Athens, Greece
  • Ikonomidis, Ignatios, National and Kapodistrian University of Athens, ATHENS, Greece
  • Dermitzaki, Eleftheria-Kleio, University Hospital of Heraklion , Heraklion, Greece
  • Lygerou, Dimitra, University Hospital of Heraklion , Heraklion, Greece
  • Theodoridis, Marios, University Hospital of Alexandroupolis, Alexandroupolis, Greece
  • Stylianou, Kostas, University Hospital of Heraklion , Heraklion, Greece
  • Tsotsorou, Ourania, ATTIKON UNIVERSITY HOSPITAL , Athens, Greece
  • Georgoulidou, Anastasia K, GENERAL HOSPITAL OF KOMOTINI, Komotini, Greece
  • Balafa, Olga, University Hospital of Ioannina, Ioannina, Greece
  • Katsoudas, Spiros, ATTIKON UNIVERSITY HOSPITAL , Athens, Greece
  • Korovesi, Anastasia, Technological Educational Institute of Crete, Heraklion, Crete, Greece
  • Chatzivasili, Dimitra, Technological Educational Institute of Crete, Heraklion, Crete, Greece
  • Markaki, Anastasia, Technological Educational Institute of Crete, Heraklion, Crete, Greece
  • Mavromatidis, Konstantinos S, GENERAL HOSPITAL OF KOMOTINI, Komotini, Greece
  • Kyriazis, Periklis Panos, Beth israel Deaconess Medical Center, Brookline, Massachusetts, United States
  • Passadakis, Ploumis, University Hospital of Alexandroupolis, Alexandroupolis, Greece
  • Vlahakos, Dimitrios V., ATTIKON UNIVERSITY HOSPITAL , Athens, Greece
Background

To examine the impact of adherence to a Mediterranean Diet (MD) on LVH and cardiac geometry in PD patients

Methods

53 PD patients (27 men) with a mean age of 62±14 years were studied. A MD adherence score (MDS) (range 0-55, 55 representing maximal adherence) was estimated according to a previously reported method (Panagiotakos 2007). Echocardiographic LVH was defined by LV mass index (LVMI) >95g/m2 in women and >115g/m2 in men. Based on LVMI and relative wall thickness (RWT), four LV geometric patterns were defined: normal (normal LVMI and RWT), concentric remodeling (normal LVMI and increased RWT>0.42), eccentric LVH (increased LVMI and normal RWT) and concentric LVH (increased LVMI and RWT)

Results

Patients with LVH (n=29) as compared to patients with no LVH (n=24) were older in age (p<0.01), had lower MDS (24.3±2.4 vs. 26.5±2.8; p<0.01) and higher malnutrition inflammation score (p<0.05), pulse pressure (p<0.05) and body mass index (p<0.01). In a multivariate logistic regression analysis adjusted for all factors mentioned above, each 1-point greater MDS was associated with 25% (OR= 0.75, 95%CI:0.57-0.93; p<0.05) lower odds of having LVH. The area under the ROC curve for predicting the development of LVH was 0.726 (p=0.005). At an optimal MDS cutoff of 25.5 the sensitivity and specificity of MDS in predicting the occurrence of LVH were 63% and 76%, respectively. Considering LV geometry, there was a progressive decrease in MDS from the normal group (26.4±3.2) to concentric remodeling (26.5±2.7), eccentric (24.7±2.3) and then to concentric LVH (24.1±2.4) group (p=0.038 for the trend). Finally, the MDS was associated positively with serum magnesium (Mg) (rho=0.34; p<0.05) and negatively with serum calcium (Ca) (rho=-0.28; p<0.05)

Conclusion

Greater adherence to a MD is associated with decreased LV mass, an important CVD risk factor and can confer protection against future cardiac dysfunction in PD patients. Whether these associations are partly mediated through opposite changes in serum Mg and Ca levels warrant further investigation

Funding

  • Clinical Revenue Support