Abstract: SA-PO447

Metabolomics Study Identifies Several Metabolites Associated with Uremic Symptoms in Advanced CKD

Session Information

Category: Chronic Kidney Disease (Non-Dialysis)

  • 306 CKD: Cognitive Dysfunction, Depression, Quality of Life

Authors

  • Hu, Jiun-Ruey, Johns Hopkins School of Public Health, Baltimore, Maryland, United States
  • Levey, Andrew S., Tufts Medical Center, Boston, Massachusetts, United States
  • Coresh, Josef, Johns Hopkins School of Public Health, Baltimore, Maryland, United States
  • Grams, Morgan, Johns Hopkins School of Public Health, Baltimore, Maryland, United States
  • Rhee, Eugene P., Massachusetts General Hospital, Boston, Massachusetts, United States
  • Shafi, Tariq, Johns Hopkins School of Public Health, Baltimore, Maryland, United States
Background

Uremic symptoms are common in patients with advanced CKD, but the toxins that cause these symptoms are unknown.

Methods

We measured metabolites in participants of the Modification of Diet in Renal Disease (MDRD) with measured GFR < 20 ml/min/1.73 m2 (N=216), using an untargeted LC/MS/MS platform. We determined the association of 667 metabolites with uremic symptom scores using linear regression adjusting for clinical factors and accounting for multiple comparisons.

Results

The mean age of the participants was 52 years and 81% were white. Uremic symptoms were common. 80% of participants had at least 1 uremic symptom. Metabolites associated with uremic symptoms are presented in the accompanying table.

Conclusion

We identified several metabolites associated with uremic toxins. Metabolomics has the potential to identify toxins that cause uremic symptoms.

Metabolite association with uremic symptoms