Abstract: TH-PO847
Increasing Staphylococcus Species Resistance in Peritoneal Dialysis-Related Peritonitis over 10 Years in Southern Taiwan
Session Information
- Peritoneal Dialysis - I
November 02, 2017 | Location: Hall H, Morial Convention Center
Abstract Time: 10:00 AM - 10:00 AM
Category: Dialysis
- 608 Peritoneal Dialysis
Author
- Chen, Hoching, E-Da hospital, Kaohsiung City, TAIWAN, Taiwan
Background
Peritonitis remains the major complication of peritoneal dialysis. Staphylococcus species are the most associated gram-positive peritoneal peritonitis. The increasing antimicrobial resistance rate has become a very important burden when considering the initial choice of antibiotics. The aim of this investigation was to exam the trends of Staphylococcus species, resistance rate and the clinical outcomes from 2006 to 2015 in southern Taiwan.
Methods
We retrospectively investigated all peritoneal dialysis-related peritonitis episodes in southern Taiwan between January 2006 and December 2015. We also evaluated the clinical characteristics, microbiology prevalence, resistance incidence of Staphylococcus species, and outcomes.
Results
Out of 244 episodes of peritonitis, Staphylococcus species accounted for around 30% gram positive bacteria. Methicillin resistance rate among staphylococcus species infection has greatly increased to 64% in 2015 both in Staphylococcus aureus and Coagulase-negative Staphylococci in southern Taiwan. Importantly, Methicillin resistance Staphylococcus species (59.1%) has significant higher hospitalization rate compare to Methicillin-sensitive Staphylococcus species(34.6%) (p<0.01). However, the catheter removal rate and transfer to hemodialysis didn't have a difference between two groups.
Conclusion
Peritonitis is the most serious complication in peritoneal dialysis patients and microbiological trends have changed during the past 10 years at a single center in southern Taiwan. Methicillin resistance Staphylococcus species has increased significantly. Empirical initial antibiotics therapy should take in consideration according to growing resistance of microbiology.
Methicillin resistance incidence rate in Staphylococcus aureus, CoNS and Staphylococci species