Abstract: SA-PO037

The Clinical Significance of Alkaline Phosphatase Activity in Patients with Septic AKI

Session Information

Category: Acute Kidney Injury

  • 003 AKI: Clinical and Translational

Author

  • Baek, Seung don, Mediplex Sejong Hospital, Gyeyang-gu, INCHEON, Korea (the Republic of)
Background

Evidences suggested that alkaline phosphatase attenuate inflammatory response in sepsis by lipopolysaccharide detoxification and adenosine triphosphate dephosphorylation. We sought to determine alkaline phosphatase (AP) activity change during septic acute kidney injury (AKI) and clinical parameters associated with AP activity.

Methods

In a retrospective study of the patients who underwent continuous renal replacement therapy (CRRT) due to septic AKI, we investigated the baseline, follow-up AP activity on day 3 and the associated outcomes.

Results

We analyzed baseline AP activity of 155 patients and day 3 AP activity of 123 patients. Baseline AP activity of 90 (59–133) U/L increased to 105 (79–156) U/L on day 3, of which liver and bone isoforms increased significantly, but intestine isoforms did not reach statistical significance. Baseline AP activity did not show an association with renal and inflammatory biomarkers, or outcomes. Also, it did not differ significantly between 75 survivors and 80 non-survivors (p=0.155). Day 3 AP activity increased in 70.6% of patients with mean difference of 19 (-3 to 53) U/L. Day 3 AP activity showed weak correlation with length of ICU stay (r=0.205, p=0.023) and length of hospital stay (r=0.190, p=0.036), however, not with survival (r=-0.035, p=0.698).

Conclusion

Endogenous AP activity modestly, but significantly increased in 70.6% of patients with septic AKI. However, neither baseline nor follow-up AP activity was associated with survival.