Abstract: PUB130
Prevalence of the Chronic Inflammatory State and Relationship with Prealbumin and Morbimortality in Patients with CKD
Session Information
Category: Dialysis
- 801 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Navarro, Ana Yadira, Fresenius Medical Care Ecuador, Quito, Pichincha, Ecuador
- Perez, Ailiyomar, Menydial, Riobamba, Chimborazo, Ecuador
- Lino, Ricardo J., Baxter Ecuador SA, Quito, Pichincha, Ecuador
Background
The chronic inflammatory state is common in patients on hemodialysis (HD), the evaluation of the clinical and nutritional status of patients on HD is essential. High mortality in HD may be associated with protein wasting síndrome energy (PEW), decreased levels of prealbumins, the objective of this work is to determine the prevalence of c-reactive protein (CRP ) ≥ 9mg/L and its relationship with prealbumins <30 mg/dl, morbidity and mortality in a dialysis unit, Ecuador
Methods
cross-sectional, prospective study, 334 patients on HD, over 18 years old, with more than 3 months on dialysis, without active infectious processes at the time of sample collection, which included determination of serum levels of prealbumin and c-reactive protein, morbidities and mortalities were recorded during a period of 6 months (November 2022-April 2023), averages, percentages were determined, the Statistical analysis was performed analysis of variance and chi square
Results
55.9% men, Women 44.01%, most common etiologies DM2 43.71%, HTN 38.92%, others 17.37%. Patients with CRP ≥ 9 mg/L 40.11%, CRP <9 mg/L 59.88%. In the distribution of CRP <9 with prealbumin < 30, 87 patients were found, of these, 32% presented comorbidities, died 1%. CRP < 9 with prealbumin ≥ 30 occurred in 113 patients, 19% with comorbidities, 3 % deaths. CRP ≥ 9 and prealbumin < 30 evidence in 73 patients, 63% with comorbidities, 18 % deceased. CRP ≥ 9 and prealbumin ≥ 30 were evident in 61 patients, 30% with comorbidities, 2% deceased. A greater number of cases with comorbidities is evident in the group with CRP ≥ 9 mg/L and prealbumin <30 mg/dl with chi square 35.535 and statistical significance p= 0.0000, CI 95.0%; with a greater number of deaths in this group of patients chi square 28.258 and statistical significance p= 0.0000, CI 95.0%
Conclusion
CRP is present in the patients of our center in more than a 1/4 of the cases, are closely related to nutritional status, using prealbumin as indicator, the high incidence of morbidity and mortality in these patients is demonstrated, which imposes the need to establish early detection measures for these factors in order to carry out preventive and therapeutic management to improve the quality of life of patients and their clinical conditions.