Abstract: TH-PO739
Diabetes Distress Is High and Negatively Affects Diabetes Control in Kidney Transplant Recipients (KTR): A Prospective Study
Session Information
- Transplantation: Clinical - 1
October 24, 2024 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Transplantation
- 2102 Transplantation: Clinical
Authors
- Kukla, Aleksandra, Mayo Clinic Minnesota, Rochester, Minnesota, United States
- Sahi, Sukhdeep Singh, Mayo Clinic Minnesota, Rochester, Minnesota, United States
- Denic, Aleksandar, Mayo Clinic Minnesota, Rochester, Minnesota, United States
- Kurek, Corey, Mayo Clinic Minnesota, Rochester, Minnesota, United States
- Kaur, Ravinder Jeet, Mayo Clinic Minnesota, Rochester, Minnesota, United States
- Shaik, Afsana Ansari, Mayo Clinic Minnesota, Rochester, Minnesota, United States
- Smith, Byron H., Mayo Clinic Minnesota, Rochester, Minnesota, United States
- Diwan, Tayyab S., Mayo Clinic Minnesota, Rochester, Minnesota, United States
- Stegall, Mark D., Mayo Clinic Minnesota, Rochester, Minnesota, United States
- Kudva, Yogish C., Mayo Clinic Minnesota, Rochester, Minnesota, United States
Background
Impact of diabetes distress (DDS) on type 2 diabetes (T2D) control in KTR is unknown. Validated T2D DDS questionnaire includes emotional, physician-related, management related, and interpersonal distress components (17 points). Total scores>2 and ≥3 in each component indicate moderate and severe DDS, respectively.
Methods
We prospectively assessed DDS in 21 KTR at mean time of 2.1 (1.5) y post KT. Glucose control was assessed by Continuous glucose monitoring (CGM) metrics (Dexcom G6) worn for ten days and HbA1C.
Results
Table 1 depicts demographics and Figure 1 glucose metrics. Treatment regimens: Median DDS scores were 7 (IQR 5,13), 4 (IQR4,4), 8 (IQR 5,11), and 3 (IQR 3,5) for emotional, physician, treatment regimen, and interpersonal subscale, respectively. CGM metrics showed mean time in range (TIR; goal>70%) of 42.6 (25.2) %, and mean time in hyperglycemia of 57.4 (25.2) %. Treatment distress correlated with higher mean glucose (rs=0.44; p=0.04) and lower TIR (rs=-0.45; p=0.04) and higher HbA1c (latter in pts with no anemia) (rs=0.62; p=0.003). No correlation was found between HbA1c and CGM metrics.
Conclusion
KTR with T2D experience high DDS, which negatively impact glucose control. Efforts should be focused on reducing treatment burden.
Demographics
| Mean age (yrs) | 61.7 (9.1) |
| BMI(Kg/m2) | 32.4 (3.9) |
| Mean glucose (mg/dL)* | 212 (64.4) |
| Hb (%) | 7.8 (1.4) |
| Normal Hb (N) | 16 (69.5%) |
| On Insulin (N) | 8 (34.7%) |
| On Insulin + other anti-hyperglycemic (N) | 13 (56.5%) |
| On non-insulin (N) | 2 (8.7%) |
Funding
- Commercial Support – DEXCOM