Abstract: SA-PO0769
Effect of Mental Health on Glomerular Disease Treatment and Outcomes
Session Information
- Glomerular Research: Design, Registries, Surveys, and Epidemiology
November 08, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics
Authors
- Kim, Emily, University of Michigan, Ann Arbor, Michigan, United States
- Smerdon, Caroline, University of Michigan, Ann Arbor, Michigan, United States
- Kostelyk, Katelyn, IgA Nephropathy Foundation, Wall, New Jersey, United States
- Abdullah, Mahie M., Northwell Health, New Hyde Park, New York, United States
- Sethna, Christine B., Northwell Health, New Hyde Park, New York, United States
- Mariani, Laura H., University of Michigan, Ann Arbor, Michigan, United States
Group or Team Name
- CureGN.
Background
There is limited research on the bidirectional relationship between mental health and glomerular disease. This study investigated the prevalence of mental health diagnoses in individuals with glomerular disease and evaluated differences in disease outcome and treatment patterns based on mental health status.
Methods
CureGN is a prospective cohort study of children and adults with MCD, FSGS, MN, and IgAN. Among adults, descriptive statistics were used to assess mental health diagnosis prevalence and characterize the Patient-Reported Outcomes Measurement Information System (PROMIS) measures. Adjusted cox proportional hazards models evaluated associations between kidney failure and both mental health diagnosis and PROMIS scores. Predictors of PROMIS mental health scores were assessed through a multivariable linear mixed model.
Results
Of 1,579 participants, 332 (21%) reported depression, anxiety, ADHD, or bipolar disorder. A higher percentage with mental health diagnoses were female (54% vs 41%) and white (77% vs 67%). eGFR, UPCR, and serum albumin were similar between groups. Prevalence was lowest among Asian participants (10%) and adults aged 60+ (14%). There is no significant difference in immunosuppression treatment (IST) for participants prior to enrollment or during study follow-up.
Mental health diagnosis and PROMIS mental health score were not associated with kidney failure [HR (95% CI) 1.06 (0.73-1.53) and 1.37 (0.95-1.99)] after adjusting for demographics and education.
Predictors of PROMIS mental health scores are in [Table]. Lower scores were linked to higher UPCR, prior IST, female sex, Asian race, less than a college degree, edema, and prior mental health diagnoses.
Conclusion
Mental health diagnoses and low PROMIS scores are common in glomerular disease but were not associated with kidney failure or treatment patterns. Individuals at high risk for low mental health scores include those with high disease activity and prior mental health diagnoses.
Funding
- NIDDK Support