Kidney Week

Abstract: SA-PO0698

Blood and Urinary Uromodulin Levels in Febrile and Afebrile Children: A Prospective Study

Session Information

• Pediatric Nephrology: Transplantation, Hypertension, AKI, Genetics, and Developmental Diseases
  November 08, 2025 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Pediatric Nephrology

• 1900 Pediatric Nephrology

Authors

• Gurevich, Evgenia, Barzilai Medical Center, Ashkelon, Israel

Evgenia Gurevich, MD

• Akirav, Nofar, Barzilai Medical Center, Ashkelon, South District, Israel

Nofar Akirav

• Revivo, Elad Itzhak, Barzilai Medical Center, Ashkelon, South District, Israel

Elad Itzhak Revivo, MD

• Zion, Elena, Schneider Children's Medical Center of Israel, Petah Tikva, Center District, Israel

Elena Zion, MD

• Arazi, Eden, Ben Gurion University of the Negev, Beer Sheva, Israel

Eden Arazi, PhD

• Segev, Yael, Ben Gurion University of the Negev, Beer Sheva, Israel

Yael Segev, PhD

• Landau, Daniel, Schneider Children's Medical Center of Israel, Petah Tikva, Center District, Israel

Daniel Landau, MD

Background

Uromodulin (UMOD) is the most abundant normal urinary protein, expressed exclusively in the kidney thick ascending limb, and secreted into both luminal (urine) and basolateral (blood) compartments. UMOD has local immunomodulatory effects and plays a systemic role in granulopoiesis regulation. However, data regarding the kidney response to systemic inflammation by basolateral vs luminal UMOD secretion is not yet known. The aim of the study is to evaluate blood (B-UMOD) and urinary (U-UMOD) UMOD in febrile vs non-febrile patients and their correlation with inflammatory markers.

Methods

This prospective study included children (age 0-16 years) admitted to BUMC with fever >38^oC of non-renal source (F), and non-febrile children as controls (C). B-UMOD and U-UMOD were analyzed using Biovender Human UMOD ELISA kit.

Results

Nineteen febrile patients and 19 controls were recruited. F patients were younger than C (mean (SD) 51±48 vs 99±55 months, p<0.01). CRP was higher in F vs C [median (IQR): 25.4 (12.9, 62.9) vs 0.6 (0.6, 1.2) mg/L, p<0.001]. B-UMOD and U-UMOD were higher in F vs C [median (IQR) B-UMOD: 14608 (10848, 29915) vs 9805 (6511,14270) pg/ml, p=0.03; U-UMOD: 700 (274,1309) vs 301 (84,636) pg/ml, p=0.04]. There was a positive correlation between B-UMOD and U-UMOD (R=0.5), U-UMOD and CRP (R=0.45), and B-UMOD and WBC (R=0.51), without age correlation.

Conclusion

Both luminal and basolateral UMOD secretion were increased in non renal febrile disease, supporting the kidney's participation in systemic inflammation. B-UMOD/WBC positive correlation is consistent with the known role of UMOD in the granulopoiesis pathway. A larger cohort is needed to confirm this data.

Digital Object Identifier (DOI)

• doi: 10.1681/ASN.2025spmtmcq2