Abstract: SA-PO0583
Establishing the First National ADPKD Clinic in Kuwait: Integrating Multidisciplinary Care and Precision Diagnostics
Session Information
- Cystic Kidney Diseases: Clinical Research
November 08, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Genetic Diseases of the Kidneys
- 1201 Genetic Diseases of the Kidneys: Monogenic Kidney Diseases
Authors
- Bahbahani, Yousif, ADPKD National Clinic, Mubarak Al-Kabeer Hospital, Kuwait, Kuwait
- Al Rajab, Heba, ADPKD National Clinic, Mubarak Al-Kabeer Hospital, Kuwait, Kuwait
- Almomen, Mohammad, ADPKD National Clinic, Mubarak Al-Kabeer Hospital, Kuwait, Kuwait
- Almutawa, Sarah F A M A, ADPKD National Clinic, Mubarak Al-Kabeer Hospital, Kuwait, Kuwait
- Ayoub, Medhat N., ADPKD National Clinic, Mubarak Al-Kabeer Hospital, Kuwait, Kuwait
- Bahbahani, Hamad Mahdi, ADPKD National Clinic, Mubarak Al-Kabeer Hospital, Kuwait, Kuwait
- Alsharhan, Loulwa, ADPKD National Clinic, Mubarak Al-Kabeer Hospital, Kuwait, Kuwait
- Alherz, Hawraa, ADPKD National Clinic, Mubarak Al-Kabeer Hospital, Kuwait, Kuwait
- Assiri, Danah, ADPKD National Clinic, Mubarak Al-Kabeer Hospital, Kuwait, Kuwait
- Albetar, Taimaa Ali, ADPKD National Clinic, Mubarak Al-Kabeer Hospital, Kuwait, Kuwait
- Alhaddad, Fatimah Adel, ADPKD National Clinic, Mubarak Al-Kabeer Hospital, Kuwait, Kuwait
- Mihdawi, Duaa Zeyad, ADPKD National Clinic, Mubarak Al-Kabeer Hospital, Kuwait, Kuwait
- Abdalla, Sherok Akram, ADPKD National Clinic, Mubarak Al-Kabeer Hospital, Kuwait, Kuwait
- Aldallal, Fatma Y, ADPKD National Clinic, Mubarak Al-Kabeer Hospital, Kuwait, Kuwait
- Abu-Farha, Mohamed, ADPKD National Clinic, Mubarak Al-Kabeer Hospital, Kuwait, Kuwait
- Ali, Hamad, ADPKD National Clinic, Mubarak Al-Kabeer Hospital, Kuwait, Kuwait
Background
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common hereditary kidney disorder worldwide, yet its diagnosis and management remain fragmented in many regions. In February 2023, we launched Kuwait’s first dedicated ADPKD clinic at the Mubarak Al-Jaber Al-Sabah Dialysis Center, aiming to deliver integrated, patient-centered care through early diagnosis, genetic counseling, and access to disease-modifying therapy.
Methods
This cross-sectional report summarizes the outcomes of the clinic from February 2023 to December 2024. Patients with clinically suspected or confirmed ADPKD were evaluated by a multidisciplinary team comprising nephrologists, geneticists, radiologists, and pharmacologists. Diagnostic work-up included PKD-specific MRI for structural evaluation and targeted gene panel testing. Patients were screened for Tolvaptan eligibility following international guidelines. Genetic counseling was offered to all patients and families undergoing testing.
Results
A total of 80 patients were enrolled. MRI-based total kidney volume (TKV) screening was completed in 70 patients (87.5%), while 58 patients (72.5%) underwent genetic testing, with 41 (71%) testing positive for PKD1 or PKD2 mutations. Genetic counseling sessions were provided to all individuals undergoing testing, including 18 families identified for cascade screening, which revealed 22 additional at-risk individuals. Tolvaptan therapy was initiated in 13 patients; 4 subsequently discontinued (3 due to side effects and 1 non-Kuwaiti patient due to medication unavailability). Currently, 9 patients are maintained on Tolvaptan, and 13 others are in the final stages of eligibility assessment. All patients are being followed through a dedicated ADPKD registry, supporting both clinical tracking and future research.
Conclusion
The ADPKD clinic in Kuwait exemplifies a patient-centered, multidisciplinary model for hereditary kidney disease care. By integrating genetic diagnostics, counseling, MRI-based risk stratification, and access to Tolvaptan, we have established a replicable framework that improves care and enables translational research in ADPKD.