Abstract: SA-PO0847
Cnm-Positive Streptococcus mutans Is Specifically Associated with IgAN in Various Kidney Diseases
Session Information
- Glomerular Management: Real-World Lessons and Emerging Therapies
November 08, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics
Authors
- Misaki, Taro, Seirei Hamamatsu Byoin, Hamamatsu, Shizuoka Prefecture, Japan
- Suehiro, Yuto, Osaka Daigaku, Suita, Osaka Prefecture, Japan
- Naka, Shuhei, Okayama Daigaku, Okayama, Okayama Prefecture, Japan
- Matsuoka, Daiki, Okayama Daigaku, Okayama, Okayama Prefecture, Japan
- Kana, Suehara, Okayama Daigaku, Okayama, Okayama Prefecture, Japan
- Ito, Seigo, Jieitai Iruma Byoin, Iruma, Saitama Prefecture, Japan
- Nomura, Ryota, Hiroshima Daigaku, Higashihiroshima, Hiroshima Prefecture, Japan
- Nagasawa, Yasuyuki, Hyogo Ika Daigaku, Nishinomiya, Hyogo Prefecture, Japan
- Matsumoto-Nakano, Michiyo, Okayama Daigaku, Okayama, Okayama Prefecture, Japan
- Nakano, Kazuhiko, Osaka Daigaku, Suita, Osaka Prefecture, Japan
Background
We previously reported an association between the presence of cnm-positive Streptococcus mutans in the oral cavity and IgA nephropathy (IgAN). However, it remains unclear whether this association is specific to IgAN among various kidney diseases. This study aimed to evaluate the association between cnm-positive Streptococcus mutans and various kidney diseases in patients who underwent renal biopsy.
Methods
A total of 294 patients who underwent renal biopsy and provided informed consent between May 2017 and March 2024 were enrolled in the chronic kidney disease (CKD) group. The control group comprised 81 individuals with an estimated glomerular filtration rate (eGFR) >60 mL/min/1.73 m2 and no proteinuria. Saliva samples were collected from all participants, stored at −20°C, and analyzed using polymerase chain reaction (PCR) to detect S. mutans and cnm-positive S. mutans. Associations between cnm-positive S. mutans and clinical parameters were subsequently assessed.
Results
The prevalence of cnm-positive S. mutans was significantly higher in the CKD group compared to the control group (21.8% vs. 11.1%, p < 0.05). Logistic regression analysis adjusted for age and sex confirmed a significant association between cnm-positive S. mutans and CKD (p < 0.05).
Among various kidney diseases, higher prevalences of cnm-positive S. mutans were observed in patients with lupus nephritis (31.6%), membranous nephropathy (29.2%), and IgAN (23.6%), suggesting a potential association with immune complex–mediated diseases. However, logistic regression analysis identified a statistically significant association only between cnm-positive S. mutans and IgAN (p < 0.05).
Conclusion
cnm-positive S. mutans may be associated with immune complex–mediated kidney diseases, with a specific and significant association observed in patients with IgA nephropathy.