Abstract: FR-OR081
Oral Antibiotic Therapy and Hospitalization in Peritoneal Dialysis-Associated Peritonitis
Session Information
- What's New at Home (Dialysis)?
November 07, 2025 | Location: Room 351D, Convention Center
Abstract Time: 05:50 PM - 06:00 PM
Category: Dialysis
- 802 Dialysis: Home Dialysis and Peritoneal Dialysis
Authors
- Lazar, Rachael, DaVita Inc, Denver, Colorado, United States
- Zywno, Meredith L., DaVita Inc, Denver, Colorado, United States
- Shapiro, Mark H., DaVita Inc, Denver, Colorado, United States
- Weinhandl, Eric D., Davita Clinical Research, Minneapolis, Minnesota, United States
- Naljayan, Mihran V., DaVita Inc, Denver, Colorado, United States
Group or Team Name
- DaVita Patient Safety Organization, Denver, CO.
Background
During peritoneal dialysis (PD), peritonitis (PTN) can result in hospital admission or permanent discontinuation of PD. When a patient experiences PTN symptoms outside clinic hours, immediate initiation of intraperitoneal (IP) antibiotics may be infeasible. We assess whether use of a one-time (“bridge”) oral antibiotic may improve outcomes in this setting.
Methods
We conducted a case-control study to assess the impact of oral antibiotic therapy (OBT) on hospitalization for PTN, relative to PTN not requiring hospitalization. Cases were accrued from 6/1/23 to 7/31/24 among PD patients at a large dialysis provider and defined by hospitalization within 30 days of PTN diagnosis. Controls were non-hospitalized PTN events. Case-control pairs (N=741) were matched on demographic and clinical factors.
Results
OBT use was documented in 31% of PTN events (total N=2981) during the 13-month period. A lower proportion of hospitalized cases (28%) versus non-hospitalized controls (31%) used OBT, although this association was not significant (OR=0.86, 95% CI: 0.69,1.08). The protective effect of OBT use on hospitalization was significant for events with gram-positive culture (OR=0.72, 95% CI: 0.56,0.92).
Conclusion
Use of an oral antibiotic was associated with lower odds of hospitalization after a PTN diagnosis, particularly for events associated with a gram-positive organism. These results suggest that patients with suspected PTN may benefit from oral antibiotic therapy as a bridge to IP antibiotics.