Abstract: SA-PO0547
Attribute-Based Cross-Classification of ADPKD Complications: A Nationwide Cohort Study from Japan
Session Information
- Cystic Kidney Diseases: Clinical Research
November 08, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Genetic Diseases of the Kidneys
- 1201 Genetic Diseases of the Kidneys: Monogenic Kidney Diseases
Authors
- Kataoka, Hiroshi, Tokyo Joshi Ika Daigaku, Shinjuku, Tokyo, Japan
- Hoshino, Junichi, Tokyo Joshi Ika Daigaku, Shinjuku, Tokyo, Japan
- Nishio, Saori, Hokkaido Daigaku, Sapporo, Hokkaido Prefecture, Japan
- Hiromura, Keiju, Gunma Daigaku Daigakuin Igakukei Kenkyuka Igakubu, Maebashi, Gunma Prefecture, Japan
- Isaka, Yoshitaka, Osaka Daigaku, Suita, Osaka Prefecture, Japan
- Muto, Satoru, Juntendo Daigaku Igakubu Fuzoku Nerima Byoin, Nerima, Tokyo, Japan
Background
Autosomal dominant polycystic kidney disease (ADPKD) leads to diverse complications beyond renal cysts. This study used nationwide registry data from Japan to evaluate how patient attributes influence complication risks, aiming to inform personalized and equitable care.
Methods
We performed a cross-sectional analysis using anonymized registry data from 12,466 ADPKD patients (2015–2021). Logistic regression evaluated associations between six attributes (sex, age, CKD stage, hypertension, total kidney volume [TKV], and annual TKV growth) and eight complications: intracranial aneurysms (IA), intracranial hemorrhage (ICH), valvular heart disease, liver cysts, kidney pain, urinary tract/cyst infections, gross hematuria/cyst bleeding, and colonic diverticula. Cross-classification identified high-risk subgroups.
Results
Liver cysts were most common (86.1%), followed by kidney pain (29.7%) and IA (18.5%). IA was associated with female sex (OR 1.59), age ≥50 (OR 1.34), hypertension (OR 1.53), and CKD stage 4–5 (OR 1.29). ICH was linked to hypertension (OR 2.73), age ≥50 (OR 1.36), TKV ≥2000 mL (OR 1.28), and rapid TKV growth (OR 1.22). Valvular heart disease was associated with age ≥50 (OR 1.87) and CKD stage 4–5 (OR 1.24). Liver cysts and kidney pain were more frequent in women and those with TKV ≥2000 mL. Cross-classification revealed distinct high-risk subgroups (e.g., IA in women ≥50 years: 25.3%).
Conclusion
This nationwide study demonstrates how sex, age, and disease severity shape the complications of ADPKD. Identifying disparities across subgroups supports the development of equitable, personalized screening and care strategies. These insights may inform inclusive guidelines and promote kidney health equity.
Attribute-Based Cross-Classification of ADPKD Complications