Kidney Week

Abstract: SA-PO0675

Association Between Maternal Preeclampsia and Abnormal Estimated Glomerular Filtration Rate in Adolescent Offspring Born Extremely Preterm

Session Information

• Pediatric Nephrology: Transplantation, Hypertension, AKI, Genetics, and Developmental Diseases
  November 08, 2025 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Pediatric Nephrology

• 1900 Pediatric Nephrology

Authors

• Sanderson, Keia, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

Keia Sanderson, MD, MS

• Vazquez, Jesus E, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

Jesus E Vazquez, MS

• Makker, Kartikeya, Johns Hopkins Medicine, Baltimore, Maryland, United States

Kartikeya Makker, MBBS, MPH

• Defreitas, Marissa J., University of Miami Department of Pediatrics, Miami, Florida, United States

Marissa J. Defreitas, MD

• South, Andrew M., Atrium Health Wake Forest Baptist, Winston-Salem, North Carolina, United States

Andrew M. South, MD, MS

• Isaac, Jaya, Montefiore Medical Center, New York, New York, United States

Jaya Isaac, MD

• Aschner, Judy L, Hackensack Meridian Health Inc, Nutley, New Jersey, United States

Judy L Aschner, MD

• Reynolds, Monica Lona, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

Monica Lona Reynolds, MD, MS, FASN

• Kucirka, Lauren M., The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

Lauren M. Kucirka, MD, PhD

• Reidy, Kimberly J., Montefiore Medical Center, New York, New York, United States

Kimberly J. Reidy, MD

• Vaidya, Ruben, Baystate Medical Center Department of Pediatrics, Springfield, Massachusetts, United States

Ruben Vaidya, MD

• Jensen, Elizabeth T., Atrium Health Wake Forest Baptist, Winston-Salem, North Carolina, United States

Elizabeth T. Jensen, PhD, MPH

• Singh, Rachana, Tufts Medical Center, Boston, Massachusetts, United States

Rachana Singh, MD, MS

• Fry, Rebecca, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

Rebecca Fry, PhD

• O'Shea, Michael, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

Michael O'Shea, MD, MPH

Background

Maternal pre-eclampsia and preterm birth are common conditions impacting the maternal-child dyad. It is not known whether maternal pre-eclampsia is associated with offspring CKD. Our objective is to evaluate the association between maternal pre-eclampsia and abnormal estimated glomerular filtration rate (eGFR) among offspring adolescents born extremely preterm (<28 weeks gestation).

Methods

The multi-center Extremely Low Gestational Age Newborn study enrolled infants (n=253) born extremely preterm between 2002-2004 and collected serum creatinine during adolescence (age 17-19 years). The primary exposure was maternal pre-eclampsia, and the primary outcome was abnormal adolescent offspring eGFR defined as a serum creatinine Under 25 CKiD eGFR of <90ml/min/1.73m² . We employed a logistic regression model adjusted for maternal age, pre-pregnancy diabetes, obesity, and chronic hypertension.

Results

9.5% of mothers had pre-eclampsia, and 32% of extremely preterm born adolescent offspring had an abnormal eGFR. Most mothers with pre-eclampsia also had pre-pregnancy chronic hypertension (96%). After adjusting for maternal comorbidities, including pre-pregnancy chronic hypertension, maternal pre-eclampsia was not associated with adolescent offspring eGFR (adjusted OR 1.1, 95% CI 0.3-3.6).

Conclusion

There was no significant association between maternal pre-eclampsia and adolescent offspring eGFR after adjusting for maternal comorbidities. Future research is needed evaluate the effect modification between maternal chronic hypertension, pre-eclampsia, and offspring kidney function.

Funding

• NIDDK Support

Digital Object Identifier (DOI)

• doi: 10.1681/ASN.2025f2252kfc