Abstract: SA-PO0567
Modified Simpson Ultrasound Method for Height-Adjusted Total Kidney Volume Estimation in ADPKD
Session Information
- Cystic Kidney Diseases: Clinical Research
November 08, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Genetic Diseases of the Kidneys
- 1201 Genetic Diseases of the Kidneys: Monogenic Kidney Diseases
Authors
- Alsaegh, Riyadh Muhi Abbood, University of Kerbala College of Medicine, Department of Medicine, Karbala, Iraq
- Al-Mukhtar, Maha Abdulrasool, Al-Saegh Center for Nephrology and Kidney Transplantation, Karbala, Iraq
- Al-Saegh, Aya Riyadh, Al-Saegh Center for Nephrology and Kidney Transplantation, Karbala, Iraq
- Al-Saegh, Ameer Riyadh, Al-Saegh Center for Nephrology and Kidney Transplantation, Karbala, Iraq
Group or Team Name
- Al-Saegh Research Group.
Background
Height-adjusted TKV via Magnetic Resonance Imaging (MRI) is standard for ADPKD but costly.We assessed a novel ultrasound(US)-based modified Simpson method,adapted from echocardiography,to improve volume accuracy over ellipsoid estimates.
Methods
This cross-sectional study included 85 ADPKD patients from Al-Saegh Center, Karbala,Iraq.Kidney length (Z),width (X),and depth (Y) were measured at six transverse levels via US.Volume per disc was calculated as TKV = ∑ π × (Xi/2) × (Yi/2) × 1 cm.Bilateral volumes were summed and adjusted for height to yield htTKV.Patients were stratified by Mayo risk groups.ROC,Pearson correlation, and ANOVA were used to compare this method with MRI and ellipsoid-based US.
Results
Among 85 patients,htTKV stratified three risk groups.An inverse correlation was seen between htTKV and eGFR (r = –0.45, p < 0.01).eGFR differed by group (ANOVA p = 0.04).ROC (Figure 2) showed AUC 1.00 for Mayo 1D–1E.The disc method showed 94% sensitivity, 99% specificity,outperforming ellipsoid US.
Conclusion
This US method estimates htTKV, correlates with MRI,and stratifies ADPKD by Mayo class.Multicenter validation is underway.We thank the Alsaegh Research Group and patients.
Table1:Mean eGFR across htTKV categories
| htTKV category | mean eGFR ml/min/1.73 m2 | 95% CI (lower-upper) | P value |
| increase (>400 ml/m2) | 39.06±14.9 | 22.9(16.1-62.1) | 0.04 |
| Decreased (<200 ml/m2) | 24.93±12.4 | 11.7 (13.2-36/7) | 0.04 |
| Normal (200-400 ml/m2) | 43.06±19.1 | 8.19(34.9-51.3 | 0.04 |
htTKV: Height adjusted total kidney volume, eGFR: estimated glomerular filtration rate, CI: confidence interval.
Figure 1. Kidney ultrasound shows length (Z), width (X), depth (Y), and disc segmentation for volume.
Figure 2. ROC curve for Simpson method prediction of Mayo 1D–1E.
Funding
- Commercial Support – alsaegh center for dialysis and kidney disease