Abstract: PUB114
Sex Differences in Clinical Characteristics and Outcomes Among Japanese Patients on Peritoneal Dialysis
Session Information
Category: Dialysis
- 802 Dialysis: Home Dialysis and Peritoneal Dialysis
Authors
- Watanabe, Yusuke, Saitama Ika Daigaku Kokusai Iryo Center, Hidaka, Saitama Prefecture, Japan
- Tomori, Koji, Saitama Ika Daigaku, Iruma, Saitama Prefecture, Japan
- Inoue, Tsutomu, Saitama Ika Daigaku, Iruma, Saitama Prefecture, Japan
- Okada, Hirokazu, Saitama Ika Daigaku, Iruma, Saitama Prefecture, Japan
Background
Peritoneal dialysis (PD) treatment duration remains limited globally, with major causes of discontinuation including PD-related infections and inadequate solute and fluid management. The Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) has identified male sex, obesity, and diabetes as predictors of PD withdrawal. However, data on sex-specific differences in PD outcomes are limited. This study aimed to examine sex-based differences in clinical characteristics and PD outcomes using a nationwide Japanese registry.
Methods
Clinical Information of adult (Age≧20 years old) Japanese PD patients was extracted from the Japanese Society for Dialysis Therapy Renal Data Registry (JRDR) using the Web-based Analysis of Dialysis Data Archives (WADDA) system as of the end of 2012 through to the end of 2022, including 80,789 PD patients (mean of 7,344 per year). Clinical characteristics and PD outcomes were compared between male and female patients. Data were statistically analyzed using student’s t-tests．
Results
Across all years, male patients had a significantly shorter PD treatment duration than female patients (mean ± SD: 29.1 ± 1.5 vs. 35.6 ± 2.5 months, p < 0.0001). The prevalence of diabetes (58.1 ± 1.5 vs. 43.6 ± 1.4%, p < 0.0001) and mean BMI (23.8 ± 0.2 vs. 22.7 ± 0.1, p < 0.0001) were higher in males. Total Kt/V (1.87 ± 0.1 vs. 2.00 ± 0.1, p = 0.003) and fluid removal [(PD drainage volume + urine volume)/body weight/day: 121.4 ± 5.0 vs. 131.5 ± 5.6 mL/kg/day, p = 0.0002] were lower in males.
PD-related Infection rates were also higher in males: peritonitis (0.22 ± 0.01 vs. 0.19 ± 0.02 episodes/patient-year, p = 0.024) and exit-site infections (0.38 ± 0.006 vs. 0.33 ± 0.04 episodes/patient-year, p = 0.07).
Conclusion
Male PD patients in Japan exhibit a shorter treatment duration, along with inferior solute and fluid control and higher peritonitis rates compared to females. These findings suggest that sex-based physiological or behavioral differences may impact PD outcomes and underscore the need for sex-specific strategies to optimize PD management.