Abstract: PUB194
Association Between APOL1 Gene High-Risk Alleles and Cardiovascular Disease in Patients with CKD at Aminu Kano Teaching Hospital in Kano, Nigeria
Session Information
Category: Genetic Diseases of the Kidneys
- 1202 Genetic Diseases of the Kidneys: Complex Kidney Traits
Author
- Nalado, Aishatu Muhammad, Bayero University, Kano, Kano, Nigeria
Group or Team Name
- African Center of Excellence.
Background
Chronic kidney disease (CKD) has become an increasingly important cause of morbidity and mortality worldwide. It is a major global health burden.
Individuals of African ancestry have a higher risk of developing CKD, faster progression to kidney failure and poorer outcomes.
This research aims to determine the association between APOL1 gene high-risk alleles and cardiovascular diseases in patients with CKD at Aminu Kano Teaching Hospital (AKTH).
Methods
The study was a hospital-based cross-sectional study involving patients with CKD attending the Nephrology Clinic and those on maintenance hemodialysis at AKTH Hospital over a period of 3 months. Eighty patients with CKD (Group 1) . Two sets of control participants comprising eighty age- and sex-matched individuals with cardiovascular disease with no CKD (Group 2) and eighty age- and sex-matched individuals without evidence of kidney disease or CVD (Group 3) were recruited from the hospital community as controls.
Results
The prevalence among CKD participants of hypertension was 53.2%, peripheral Arterial Disease (PAD) 81.0%, diabetes mellitus (DM) 47.2%, Myocardial infarction (MI) 41.9%, Congestive heart failure (CHF) 34.4%, and stroke 46%. The CKD participants had a higher Low-density lipoprotein (LDL) cholesterol of 88.9%, low serum calcium of 77.7%, higher serum uric acid 55.6%, and all the CKD participants had low serum albumin and albuminuria >30mg/mmol. The study also found that 12.5% of cases with CKD have APOL1 HR alleles,
Conclusion
The study showed a distribution of CVD risk factors and complications among CKD patients, with notable differences between the LR (Low-risk APOL1 alleles) and HR (High-risk APOL1 alleles) groups in terms of factors like stroke, proteinuria, and serum phosphate levels. However, the study found a significant association between high-risk APOL1 variants and proteinuria, and stroke but no association with hypertension, diabetes mellitus, and other cardiovascular diseases.
Funding
- Government Support – Non-U.S.