Kidney Week

Abstract: FR-PO0128

Association Between High-Density Lipoprotein to Low-Density Lipoprotein Ratio and Contrast-Induced AKI Based on the In-Hospital AKI Electronic Monitoring System

Session Information

• AKI: Epidemiology and Clinical Trials
  November 07, 2025 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Acute Kidney Injury

• 102 AKI: Clinical, Outcomes, and Trials

Authors

• Xu, Youjun, Ningbo No 2 Hospital, Ningbo, Zhejiang, China

Youjun Xu

• Zhou, Fangfang, Ningbo No 2 Hospital, Ningbo, Zhejiang, China

Fangfang Zhou

• Zheng, Xingyue, Ningbo No 2 Hospital, Ningbo, Zhejiang, China

Xingyue Zheng

• Wang, Lailiang, Ningbo No 2 Hospital, Ningbo, Zhejiang, China

Lailiang Wang

• Ding, Wenqing, Ningbo No 2 Hospital, Ningbo, Zhejiang, China

Wenqing Ding

• Luo, Qun, Ningbo No 2 Hospital, Ningbo, Zhejiang, China

Qun Luo, MD

Background

The objective of this study was to investigate the relationship between the High-Density Lipoprotein (HDL) to Low-Density Lipoprotein (LDL) ratio and the risk of Contrast-Induced Acute Kidney Injury (CI-AKI).

Methods

A real-time, in-hospital AKI electronic monitoring system was designed based on current KDIGO AKI criteria. Based on the system, data were automatically collected from patients who underwent elective angiography and interventional therapy at Ningbo No. 2 Hospital between June 1, 2019, and May 31, 2024.

Results

A total of 3,139 patients were included in the study, of whom 2,177 were male (69.35%), with a median age of 68 years. Among these patients, 300(9.56%) were diagnosed with CI-AKI. The HDL to LDL ratio in the CI-AKI group was 0.40 [0.32, 0.53], while the ratio in the non-AKI group was 0.44 [0.35, 0.57] (P < 0.001). Restricted cubic splines (RCS) indicated the nonlinear correlation between the HDL-to-LDL ratio and AKI (nonlinear, P=0.047, Figure 1). HDL to LDL ratio <0.43 is associated with an increased risk of AKI(OR=1.41,95%CI=1.11-1.79, P=0.005). In the stratified analysis, significant interactions were observed between the HDL-to-LDL ratio and the use of vasoactive drugs, spironolactone, ACEI/ ARB,NSAIDs and baseline eGFR (Figure 2).

Conclusion

The decreased HDL-to-LDL ratio was closely correlated with the incidence of CI-AKI, suggesting that this ratio could potentially serve as a new predictor for CI-AKI.

Figure 1 RCS curve associations between the HDL-to-LDL ratio and AKI

Subgroup analysis of the association between HDL-to-LDL ratio and AKI

Digital Object Identifier (DOI)

• doi: 10.1681/ASN.2025nhz0d4p4