Abstract: SA-PO1099
Inflammaging in Octogenarians with CKD: Gender Influence
Session Information
- Geriatric Nephrology
November 08, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Geriatric Nephrology
- 1300 Geriatric Nephrology
Authors
- Cigarran, Secundino, Hospital Ribera Polusa, Lugo, Spain
- Sanjurjo Amado, Ana Maria, Hospital da Mariña, Burela, Lugo, Spain
- Vázquez Rodríguez, Raquel, Hospital Ribera Polusa, Lugo, Spain
- Santidrián Novo, Amaia, Hospital Ribera Polusa, Lugo, Spain
- Rios, Jose, Hospital Clinic de Barcelona, Barcelona, Spain
- Gonzalez-Parra, Emilio E., Fundación Jimenez Díaz, Madrid, Spain
- Barril, Guillermina, Fundacion Investigaciones Biomedicas, Madrid, Spain
Background
Ageing and age-related diseases share fundamental mechanisms that primarily converge on inflammation. With age, a chronic, sterile, low-grade inflammation known as inflammaging occurs, contributing to the development of age-related diseases.
The aim is to assess the inflammatory status in octogenarians with CKD who were followed in a Nephrology Unit conducted as an observational, prospective, and longitudinal study over 14 years, with a comparison of gender differences.
Methods
A total of 724 patients (335 women (46.4%), age 84.7±3.5 years,42.1% diabetic, GFR-EPI 36.6±14.7 ml/min/1.73m2, UACR 238.2±617.7 mg/g creatinine) were included and compared by gender.All patients underwent analysis of biochemical markers of nutrition, inflammation,and cardiovascular risk.Vascular age was obtained using AFD AGEs Reader (Diagnoptics Technologies BV, Groningen, Netherlands) according to the Koetsner formula (Vascular age = AFD-0.83/0.024).The cut-off point for CRP was 0.6 mg/dl.Data were processed using SPSS 28 for Windows.Statistical significance was considered at p <0.005.
Results
93 men(23.9%) and 94 women(28.1%)showed CRP >0.6 mg/dl p<0.001. 42.4% were diabetics in both groups.There were no differences in age, GFR, and UACR. Obesity was more frequent in women.
Inflammation in obese and Diabetic patients affected nutritional and cardiovascular markers in both groups.. Women shows an increase in vascular age.[Fig.1].
Conclusion
In octogenarians, inflammation is present in metabolic syndrome ( Diabetic and obesity) in both groups. Obesity is more prevalent in women.It could contributes to inflammatory aging, which can worsen cardiovascular disease. Given the increasing prevalence of CKD in this population, specialized care is required.
Funding
- Private Foundation Support