Abstract: FR-PO0075
Trends in AKI-Related Deaths in the United States, 2018-2023
Session Information
- AKI: Epidemiology, Risk Factors, and Prevention
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Acute Kidney Injury
- 101 AKI: Epidemiology, Risk Factors, and Prevention
Authors
- Saeed, Fatima, King Edward Medical University, Lahore, Punjab, Pakistan
- Farooq, Arham Khalid, King Edward Medical University, Lahore, Punjab, Pakistan
- Rehman, Wania, King Edward Medical University, Lahore, Punjab, Pakistan
- Ghani, Abdul Sami Ur Rehman, King Edward Medical University, Lahore, Punjab, Pakistan
- Nawaz, Ayeza, King Edward Medical University, Lahore, Punjab, Pakistan
- Saleem, Zainab, King Edward Medical University, Lahore, Punjab, Pakistan
- Talab, Tehreem, King Edward Medical University, Lahore, Punjab, Pakistan
- Aslam, Mian Muhammad Salman, University of Michigan, Ann Arbor, Michigan, United States
Background
Acute kidney injury (AKI), a clinical syndrome characterised by an abrupt rise in serum creatinine and/or oliguria, poses a significant public health and economic burden.
Methods
CDC WONDER death certificates database (ICD-10 N17; 2018–2023) to rate age-adjusted mortality rates (AAMRs) and crude mortality rates (CMRs) per 100,000 persons. AAMRs were stratified by year, gender, race, and region. Annual percentage changes (APCs) with 95% CI were obtained using joinpoint regression.
Results
Between 2018 and 2023, 569,877 deaths were related to AKI. AAMR rose from 16.0 to 27.1 (APC = 15.08) and was higher in men vs. women (28.9 vs. 18.77). NH Black had the highest overall AAMR (31.29), followed by NH American Indian or Alaskan Native (25.32), NH White (22.84), Hispanic (22.58) and NH Asian or Pacific Islander (13.91). CMRs increased with age, peaking at 366.1 in ≥85 years. AAMR was highest in the South (25.91), followed by the West (23.34), Midwest (22.50) and Northeast (18.20), with the greatest CMRs in rural areas. The highest AAMR was observed in Kentucky (41.69), Texas (35.66), South Dakota (35.02) and South Carolina(34),whereas the lowest AAMR was observed in New York (13.19), Hawaii (14.19), Maine (15.04) and Connecticut (15.87). The location of death varied, with 79.69% in medical facilities, 7.14% at the decedent’s home, 4.79% in hospices, 7.10% in nursing homes and 1.3% in other or unknown places.
Conclusion
AKI mortality rose in the US, peaking in 2021. Rates were higher in men, older adults, and NH Black individuals. Targeted interventions for high-risk groups and underserved regions are needed.