Kidney Week

Abstract: TH-PO1003

Reference Range of Glomerular Filtration Rate in a Healthy Indian Population

Session Information

• Diversity and Equity in Kidney Health
  November 06, 2025 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Diversity and Equity in Kidney Health

• 900 Diversity and Equity in Kidney Health

Authors

• Yadav, Ashok Kumar, Post Graduate Institute of Medical Education and Research, Chandigarh, CH, India

Ashok Kumar Yadav, PhD

• Kaur, Jaskiran, Post Graduate Institute of Medical Education and Research, Chandigarh, CH, India

Jaskiran Kaur, PhD

• Kaur, Rupinder, Post Graduate Institute of Medical Education and Research, Chandigarh, CH, India

Rupinder Kaur, MSW

• Agnihotri, Pratima, Post Graduate Institute of Medical Education and Research, Chandigarh, CH, India

Pratima Agnihotri, MSW

• Kumar, Vivek, Post Graduate Institute of Medical Education and Research, Chandigarh, CH, India

Vivek Kumar, MD, MBBS

• Jha, Vivekanand, The George Institute for Global Health India, New Delhi, DL, India

Vivekanand Jha, MD

Background

Recent reports from Asian countries that measured glomerular filtration rate (GFR) using exogenous markers have established the GFR range to be lower as compared to European and American population. We and others have shown that the GFR is lower in Indian populations as well.

Methods

In this study, we set out to establish the GFR range in healthy subjects of different age groups in India. This study enrolled prospective kidney donors undergoing evaluation at PGIMER Chandigarh and healthy individuals drawn from the general population using community sampling in Chandigarh. Subjects of either sex, ≥18 years of age, and with no chronic illness were included. GFR was analysed using the plasma clearance of iohexol

Results

A total of 592 healthy subjects were included. The median age of the study subjects was 46 year and 393 (66%) were men. The mean body mass index was 26.22±4.73 Kg/m². Protein intake was 0.5 (0.4, 0.7) g/kg/day and total muscle mass was 49±9 kg. The median (25th , 75th percentile) and mean measured GFR were 82 (70, 95) 84±22 ml/min/1.73m² (range: 39 -197 ml/min/1.73m²), respectively. Table 1 provides a breakdown of GFR in various subgroups. The mGFR was significantly lower in women as compared to men [81 (68, 95) vs 86 (76, 96) ml/min/1.73m², p=0.036). With respect to age group, overall difference in decline was observed with increase in age, although no difference was observed below the age of 40 years. Table 1 also shows age related decline which was variable between the male and females. GFR below 40 years was 90 (80, 103) ml/min/1.73m².

Conclusion

In conclusion, this study shows the low GFR in Indian Population and emphasizes the need to use ethnically tailored GFR reference ranges to enhance diagnostic accuracy and equity in assessing kidney health worldwide.

Funding

• Government Support – Non-U.S.

Digital Object Identifier (DOI)

• doi: 10.1681/ASN.2025pcs57rfm