Abstract: TH-PO1061
Association of Lifestyle with New-Onset Dyslipidemia in Patients with Nondialysis-Dependent CKD: J-SHC Study
Session Information
- CKD: Epidemiology, Risk Factors, and Other Conditions
November 06, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Tasaki, Hikari, Nara Kenritsu Ika Daigaku, Kashihara, Nara Prefecture, Japan
- Kosugi, Takaaki, Nara Kenritsu Ika Daigaku, Kashihara, Nara Prefecture, Japan
- Eriguchi, Masahiro, Nara Kenritsu Ika Daigaku, Kashihara, Nara Prefecture, Japan
- Yoshida, Hisako, Osaka Koritsu Daigaku Igakubu Daigakuin Igaku Kenkyuka, Osaka, Osaka Prefecture, Japan
- Kasahara, Masato, Nara Kenritsu Ika Daigaku, Kashihara, Nara Prefecture, Japan
- Iseki, Kunitoshi, Okinawa-ken, Naha, Okinawa Prefecture, Japan
- Asahi, Koichi, Iwate Ika Daigaku, Shiwa District, Iwate Prefecture, Japan
- Yamagata, Kunihiro, Tsukuba Daigaku, Tsukuba, Ibaraki Prefecture, Japan
- Konta, Tsuneo, Yamagata Daigaku, Yamagata, Yamagata Prefecture, Japan
- Fujimoto, Shouichi, Miyazaki Daigaku, Miyazaki, Miyazaki Prefecture, Japan
- Narita, Ichiei, Niigata Daigaku, Niigata, Niigata Prefecture, Japan
- Shibagaki, Yugo, Sei Marianna Ika Daigaku Byoin, Kawasaki, Kanagawa Prefecture, Japan
- Moriyama, Toshiki, Osaka Daigaku, Suita, Osaka Prefecture, Japan
- Kondo, Masahide, Ibaraki Daigaku, Mito, Ibaraki Prefecture, Japan
- Watanabe, Tsuyoshi, Fukushima Kenritsu Ika Daigaku, Fukushima, Fukushima Prefecture, Japan
- Tsuruya, Kazuhiko, Nara Kenritsu Ika Daigaku, Kashihara, Nara Prefecture, Japan
Background
Chronic kidney disease (CKD) is a known risk factor for dyslipidemia; however, limited evidence exists regarding the impact of lifestyle habits, particularly physical activity and dietary patterns, on lipid metabolism in CKD. This study aimed to investigate the association between lifestyle factors and the incidence of dyslipidemia using data from the Japan Specific Health Checkups (J-SHC) study.
Methods
Participants aged 40 to 74 years who underwent multiple nationwide specific health checkups between 2008 and 2014 were included. Cox proportional hazards models were used to evaluate the association between baseline lifestyle habits (exercise, walking habits, and dietary intake) and the new onset of dyslipidemia, defined as the development of hypertriglyceridemia (high TG), hyper-LDL cholesterolemia (high LDL-C), or hypo-HDL cholesterolemia (low HDL-C) during follow-up.
Results
Among 38,893 individuals with CKD, during a median follow-up period of 35 months, 5,964 participants developed high TG, 7,148 developed high LDL-C, and 1,558 developed low HDL-C. In multivariable-adjusted analyses, regular exercise was significantly associated with a decreased risk (HR [95% CI]) of incident high TG (0.88 [0.83–0.93]) and low HDL-C (0.81 [0.73–0.91]). In contrast, a habit of eating before bedtime was associated with an increased risk (HR [95% CI]) of developing high TG (1.23 [1.15–1.32]), high LDL-C (1.06 [0.99–1.14]), and low HDL-C (1.25 [1.10–1.42]). Similarly, skipping breakfast was associated with an elevated risk (HR [95% CI]) for high TG (1.21 [1.11–1.32]), high LDL-C (1.21 [1.10–1.31]), and low HDL-C (1.32 [1.11–1.58]).
Conclusion
Among individuals with CKD, a regular exercise habit was independently associated with a lower risk of incident high TG and low HDL-C. In contrast, unhealthy dietary habits such as eating before bedtime and skipping breakfast were associated with an increased risk of new-onset dyslipidemia.