Abstract: TH-PO0766
Comparison of Lupus Nephritis (LN) and Non-LN in 230 Patients with Systemic Lupus Erythematosus: Unveiling Clinical and Histopathological Insights
Session Information
- Glomerular Histopathology: Evolving Insights
November 06, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics
Authors
- Dahani, Assadullah, Jinnah Post Graduate Medical Centre, Karachi, Sindh, Pakistan
- Khan, Furqan, Jinnah Post Graduate Medical Centre, Karachi, Sindh, Pakistan
- Abbas, Fakhar, University of Health Sciences, Lahore, Punjab, Pakistan
- Ali, Faique, Jinnah Post Graduate Medical Centre, Karachi, Sindh, Pakistan
- Kumari, Usha, The University of Tennessee Health Science Center College of Medicine, Memphis, Tennessee, United States
Background
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that frequently affects the kidneys. This study aims to determine the prevalence of lupus nephritis (LN) at diagnosis, classify biopsy-confirmed stages, and compare demographic, clinical, laboratory, and histopathological characteristics between LN and non-LN patients.
Methods
This observational study was conducted at Jinnah Postgraduate Medical Center, Pakistan. The study included 230 patients with known diagnosis of SLE (aged 16–60 years) using a non-consecutive sampling technique, regardless of kidney involvement.
Results
Of 230 participants, 208 (90.4%) were female, with a mean age of 26 years. LN was present in 24% of SLE patients. SLE patients with LN had significantly higher rates of frothy urine, hematuria, reduced urinary output, abnormal renal function, body swelling, pulmonary edema, and proteinuria (p < 0.001). Hypertension was more common in LN patients (26.8%) than in non-LN patients (11.5%) (p = 0.006). A significant difference (p < 0.05) in anti-dsDNA, anti-Smith, anti-SSA (Ro), anti-SSA (La), C3, C4, and lupus anticoagulant levels were noted among 2 groups. Among LN patients, focal segmental glomerulonephritis (GN) (35.7%) was the most common histopathological pattern, followed by membranous (28.6%) and diffuse (23.2%) GN (see Chart 1).
Conclusion
LN was common at initial SLE presentation and showed distinct clinical, serological, and histopathological differences. Early risk factor identification may aid in timely diagnosis and management.