Abstract: TH-PO0325
Association of Prevalent Kidney Stone Disease with Hypertension Control and Survival Among US Adults
Session Information
- Hypertension and CVD: Clinical - 1
November 06, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Hypertension and CVD
- 1602 Hypertension and CVD: Clinical
Authors
- Shringi, Sandipan, Brown University Warren Alpert Medical School, Providence, Rhode Island, United States
- Raker, Christina A., Brownhealth Biostatistics, Epidemiology, Research Design, and Informatics Core, Division of Kidney Diseases and Hypertension, Alpert Medical School of Brown University, Providence, Rhode Island, United States
- Tang, Jie, Brown University Warren Alpert Medical School, Providence, Rhode Island, United States
Background
Kidney stone (KS) disease is associated with hypertension. Here, we aim to study the association of hypertension control and survival among KS formers.
Methods
We used the National Health and Nutrition Examination Survey (NHANES) III, 2007-2018 and their linked mortality file for this study. Hypertensive index (HI) was used as a marker of blood pressure (BP) control and is defined as [(mean systolic BP-120) x (number of antihypertensive medications+1)]. Cox proportional hazard regression was used for the survival analyses.
Results
79,892 participants were eligible for the final analysis, including 4,151 prevalent KS formers of which 1,647 (45.5%) had a history of hypertension. The mean age was 59.1 years, 54% were male, and 81% were non-Hispanic White. There was a total of 410 all-cause mortalities (ACM) and 111 cardiovascular mortalities (CVM) among hypertensive KS formers (Figure 1). In unadjusted analysis, HI was associated with a higher ACM (HR 1.008, 95% CI: 1.006-1.01, p<0.001) and CVM (HR 1.01, 95% CI: 1.007-1.012, p<0.001). After multivariable adjustment for age, sex, and race, HI was only significantly associated with CVM (HR 1.004, 95% CI: 1.0006-1.008, p=0.02). Among different antihypertensives used in the study, only thiazide use was associated with a lower risk of both all-cause (HR 0.56, 95% CI: 0.32-0.95, p=0.03) and CVM (HR 0.29, 95% CI: 0.11-0.79, p=0.02) (Figure 2).
Conclusion
Among hypertensive KS formers, HI is associated with higher CVM and the use of thiazide appears to have a survival advantage.