Abstract: FR-PO1175
Predictive Value of Albuminuria and Kidney Function for Future Decline in Brain Volume: The Ohasama Study
Session Information
- CKD: Screening, Diagnosis, Serum and Urine Biomarkers, and Scoring Indices
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Nakayama, Shingo, Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, United States
- Satoh, Michihiro, Division of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan
- Yamaguchi, Satoshi, Division of Aging and Geriatric Dentistry, Department of Rehabilitation Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan
- Murakami, Takahisa, Division of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan
- Nobayashi, Hiroki, Division of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan
- Yagihashi, Takahito, Division of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan
- Tatsumi, Yukako, Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan
- Hirose, Takuo, Division of Nephrology and Endocrinology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan
- Tsubota-Utsugi, Megumi, Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan
- Hara, Azusa, Laboratory of Social Pharmacy and Epidemiology, Showa Pharmaceutical University, Tokyo, Japan
- Mori, Takefumi, Division of Nephrology and Endocrinology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan
- Asayama, Kei, Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan
- Nomura, Kyoko, Department of Environmental Health Science and Public Health, Akita University Graduate School of Medicine, Akita, Japan
- Kikuya, Masahiro, Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan
- Metoki, Hirohito, Division of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan
- Ohkubo, Takayoshi, Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan
Background
Previous studies demonstrated that albuminuria and renal dysfunction were associated with brain atrophy, but they were cross-sectional. The present prospective cohort study examined the association of albuminuria and renal function with brain volume change in an Asian general population.
Methods
We analyzed data from 114 community-dwelling participants aged ≥50 years with at least two occasions of brain magnetic resonance imaging (MRI), without history of cardiovascular disease and antihypertensive treatment in Ohasama town, Japan. Brain volumes were obtained from MRIs. The annual symmetric percentage change (ASPC) in brain volume was calculated as 200 × (volume at follow-up – volume at baseline)/(volume at follow-up + volume at baseline). Multiple regression analyses were used to assess the association between urinary albumin-creatinine ratio (UACR) or estimated glomerular filtration rate (eGFR) (based on the CKD-EPI formula) and ASPC in brain volume after adjustments for covariates. Dropout bias was adjusted by inverse probability weighting.
Results
The mean age was 66.9 years, 72.8% were women, and the mean follow-up period was 4.78 years. The multiple regression analyses showed that higher UACR was significantly associated with the ASPC of the frontal lobe (standardized regression coefficient [β] = -0.26, p= 0.018), superior frontal gyrus (β =-0.24, p= 0.028), middle frontal gyrus (β =-0.30, p= 0.0056), opercular part of the inferior frontal gyrus (β =-0.23, p= 0.040), and parahippocampal gyrus (β= -0.22, p= 0.046). UACR was not significantly associated with the other regions of the brain including hippocampus. Meanwhile, eGFR showed no significant association with ASPC of any brain region. Although we performed stratified analyses according to age and sex for the ASPC, neither UACR nor eGFR showed significant interactions with the ASPC.
Conclusion
The present study is the first to demonstrate the predictive value of albuminuria and renal function for future decline in regional brain volume. In particular, albuminuria may serve as a valuable predictor of structural changes in the brain.