Abstract: SA-PO0220
Radical Nephrectomy vs. Partial Nephrectomy in T1-2, N0, M0 Cystic Renal Cell Carcinoma
Session Information
- Onconephrology: MGRS, HSCT, Electrolytes, RCC, and More
November 08, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Onconephrology
- 1700 Onconephrology
Authors
- Asghar, Muhammad Sohaib, AdventHealth Sebring, Sebring, Florida, United States
- Braaten, Marco, Creighton University, Omaha, Nebraska, United States
- Weng, Bob, Creighton University, Omaha, Nebraska, United States
- Shaik, Afsana Ansari, Mayo Clinic Minnesota, Rochester, Minnesota, United States
- Lee, Woo Joo, AdventHealth Sebring, Sebring, Florida, United States
- Fareeduddin, Syed Khooshal, Mayo Clinic Minnesota, Rochester, Minnesota, United States
Background
Cystic renal cell carcinoma (cRCC) is an uncommon variant of renal cell carcinoma. Historically, cRCC was defined as comprising greater than 75% cystic area. While cRCC is treatable and carries a favorable prognosis, radical nephrectomy (RN) has historically been favored over partial nephrectomy (PN) due to the concern of intraoperative cyst rupture. This study compared survival outcomes of PN to RN in patients with T1-2, N0, M0 cRCC.
Methods
The NCDB was exclusively used to accumulate patients with cRCC undergoing either PN or RN with the sole inclusion criteria of ICD-O-3 code 8316, correlating to T1-2, N0, M0 RCC with cystic properties on histology. All patients with missing survival data, unknown TMN staging, T3-4, TX, N1-4, NX, M1, MX, and all surgical codes except 50, corresponding to PN, and 80, corresponding to RN were excluded. Chi-square and ANOVA were used to compare descriptive data and generated Kaplan-Meier survival curves with Log-rank test. Multivariable logistic regression and Cox proportional hazards regression analysis were used to generate odds and hazard ratios.
Results
Of the 1,302 patients with cRCC who met study inclusion criteria, 723 (55.6%) underwent partial nephrectomy and 579 (44.4%) underwent radical nephrectomy. Patients who underwent PN experienced increased overall 5-, 10-year, and mean survival compared to patients with RN (mean survival: 177 months vs. 115 months; p<.05). Multivariate analysis revealed that patients receiving RN experienced significantly increased odds of death (multivariate logistic regression OR=2.61; 95% CI 2.01-3.38) and hazard ratio (cox proportional hazard regression HR=2.21; 95% CI 1.76-2.78). Patients undergoing PN had significantly decreased surgical inpatient hospital stays (3.57 days vs. 4.16 days; p<.05), were from the highest income brackets (37.6% vs. 26.4%; p<.05), and were more likely to be treated at an academic/research facility (47.1% vs. 44.4%; p<.05). No significant differences were seen in age, sex, or race between the two groups.
Conclusion
PN is associated with improved survival compared to RN in patients with T1-2, N0, M0 cRCC.