Abstract: FR-PO1156
Triglyceride-Glucose Index and Risk of ESKD in Young Adults: A National Population-Based Cohort Study
Session Information
- CKD: Screening, Diagnosis, Serum and Urine Biomarkers, and Scoring Indices
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Kim, Jee Sung, Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea (the Republic of)
- Lee, Yu ho, Division of Nephrology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea (the Republic of)
- Chung, Sungjin, Division of Nephrology, Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea (the Republic of)
- Hwang, Hyeon Seok, Division of Nephrology, Department of Internal Medicine, Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea (the Republic of)
- Han, Kyungdo, Soongsil University Department of Statistics and Actuarial Science, Seoul, Korea (the Republic of)
- Yoon, Hye Eun, Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea (the Republic of)
Background
The triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance, has been linked to chronic kidney disease (CKD) and end-stage kidney disease (ESKD). However, its association with ESKD in young adults remains unclear. This study aimed to evaluate whether a higher TyG index is associated with increased ESKD risk in a young adult population.
Methods
This nationwide, retrospective, population-based cohort study analyzed data from 6,555,863 individuals aged 20 to 39 years between 2009 and 2012, using the Korean National Health Insurance Database. Participants were categorized into quartiles and deciles according to TyG index. The cumulative incidence and adjusted hazard ratios (aHRs) for ESKD were calculated using Cox proportional hazards models.
Results
Over a median follow-up of 10.61 years, 4,910 individuals (0.75%) developed ESKD. ESKD incidence increased steadily across higher TyG quartiles and deciles. Compared with the lowest quartile, individuals in the highest quartile had a greater risk of ESKD (aHR: 3.469; 95% CI: 3.122–3.854). Similarly, the highest decile group had a elevated risk compared to the lowest decile (aHR: 5.951; 95% CI: 5.026–7.046). These associations were consistent across subgroups stratified by age, sex, obesity, dyslipidemia, and baseline chronic kidney disease.
Conclusion
A higher TyG index is independently associated with an increased risk of ESKD in young adults. These findings suggest the TyG index may serve as a useful tool for early identification of individuals at risk for long-term kidney complications.
Figure 1. Cumulative incidence of end-stage kidney disease by TyG index quartiles: Kaplan-Meier analysis. The cumulative incidence probability is displayed on the y-axis, with different scales used across the plots. The P-value was calculated using the log-rank test.