Abstract: FR-PO0361
Inflammation Cytokines and Adipokines in Patients with Diabetes and Obesity with and Without CKD
Session Information
- Diabetic Kidney Disease: Progression, Predictive Tools, Therapeutics, and Outcomes
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Diabetic Kidney Disease
- 702 Diabetic Kidney Disease: Clinical
Authors
- Mahajan, Sandeep, All India Institute of Medical Sciences New Delhi, New Delhi, DL, India
- Subbiah, Arunkumar, All India Institute of Medical Sciences New Delhi, New Delhi, DL, India
- Rizwan, Arshi, All India Institute of Medical Sciences New Delhi, New Delhi, DL, India
Background
Epidemic of diabetes & obesity is fueling increasing cases of CKD worldwide. Mechanisms involved in complex interplay between obesity, diabetes and CKD are poorly studied, though inflammation & shift in adipokine and cytokine production towards pro-inflammatory state have been implicated
We in this cross-sectional, case control study looked at HsCRP & important pro-inflammatory (leptin, IL-6, TNF-α) & anti-inflammatory mediators (adiponectin, IL-10) in subjects with obesity alone, obesity with diabetes & obesity with diabetes & CKD & compared it with healthy controls
Methods
60 consenting subjects in each group were studied. Besides detailed history, BMI calculation; serum levels of HsCRP, adipokines (leptin & adiponectin) & cytokines (IL-6, TNF-α & IL-10) were assessed using commercially available ELISA kits
Results
Table shows demographic, clinical & study parameters of each group. Patient groups were gender matched but slightly older than controls. Obese subjects in various groups had similar BMI & waist/hip ratio. All obese groups had evidence of pro-inflammatory state as evidenced by higher HsCRP, leptin, IL6 & TNF-α than controls, with obese diabetic patients with CKD showing maximum aberrations. Levels of adiponectin were lower only in patients with obesity with complications of DM & CKD while IL-10 levels were higher in these groups
Conclusion
We document higher pro-inflammatory milieu in obese subjects, which worsens progressively with complications of DM & CKD. Though, absolute values of anti-inflammatory mediators are not affected to similar extent but they might be relatively impaired considering overall pro-inflammatory state
Demographic clinical & study parameters
| Parameter | Controls | Obese alone | Obese with DM | Obese with DM & CKD |
| Age (yr) | 43.1 ± 7.5 | 45.5 ± 6.4* | 50.4±10.5* | 51.3±12.2* |
| Male (%) | 61.6 | 60 | 53.3 | 60 |
| BMI | 22.7±2.1 | 31.8±1.4* | 31.4±2.1* | 30.4±1.8* |
| Waist/Hip ratio | 0.8±.1 | 0.9±0.2* | 0.9±0.1* | 1.0±0.1* |
| eGFR (ml/min) | 108.3±26.4 | 102.7±20.5 | 96.6±9.7*^ | 40.0±10.2*^# |
| HsCRP (mg/L) | 1.1±0.1 | 2.4±0.4* | 3.9±0.2*^$ | 8.4±0.1*^# |
| Leptin (ng/ml) | 3.7±0.2 | 58.6±5.2* | 62.3±17.2*$ | 83.4±12.2*^# |
| Adiponectin (pg/ml) | 5.3±0.7 | 5.5±0.3 | 3.7±0.9*^ | 2.9±0.6*^ |
| IL-6 (pg/ml) | 72.4±8.2 | 83.4±8.4* | 174.5±10.3*^$ | 392.9±22.2*^# |
| TNF-α (pg/ml) | 5.4±1.1 | 7.8±1.2* | 11.3±0.8*^$ | 21.6±1.9*^# |
| IL-10 (pg/ml) | 101.8±14.2 | 71.4±11.9* | 139.1±16.6*^ | 131.1±36.1*^ |
*p<0.05 vs group 1, ^ p<0.05 vs group 2, # p<0.05 vs group 3, $ p<0.05 vs group 4