Kidney Week

Abstract: PUB341

Retrospective Comparison of Kidney Transplant Outcomes in Patients with and Without Systemic Sclerosis

Session Information

• Publication Only

Category: Transplantation

• 2102 Transplantation: Clinical

Authors

• Grigoryan, Lilit, Albany Medical Center, Albany, New York, United States

Lilit Grigoryan, DO

• Wajid, Sumbal, Albany Medical Center, Albany, New York, United States

Sumbal Wajid, MBBS

• Salman, Zane L, Rensselaer Polytechnic Institute, Troy, New York, United States

Zane L Salman

• Hongalgi, Krishnakumar D., Albany Medical Center, Albany, New York, United States

Krishnakumar D. Hongalgi, MD

• Monrroy, Mauricio, Albany Medical Center, Albany, New York, United States

Mauricio Monrroy, MD

• Faddoul, Giovanni, Albany Medical Center, Albany, New York, United States

Giovanni Faddoul, MD

• Mehta, Swati, Albany Medical Center, Albany, New York, United States

Swati Mehta, MD, MBBS, FASN

Background

Scleroderma renal crisis (SRC) is one of the life threatening complications of systemic sclerosis (SSc). Up to 20-50% require long term dialysis and subsequently kidney transplant. We performed a retrospective study using the United Network for Organ Sharing (UNOS) database, to compare graft and patient survival in kidney transplantation (KT) patients with and without systemic sclerosis.

Methods

A retrospective analysis was conducted using UNOS database from 2000 to 2022. A total of 211 patients were chosen based on diagnostic coding consistent with scleroderma related diagnoses who underwent KT from deceased donors (DD) and live donors (LD). This cohort was then matched to non-SSc recipients using a propensity score matching.

Results

There was a statically significant association with poorer outcomes in both graft and patient survival from both DD, and LD following KT in our SSc cohort when compared to non-SSc cohort (Figure 1).

Conclusion

Using UNOS data from 211 SSc patients, we found statistically significant worse outcomes in both graft and patient survival when compared to matched controls in both DD and LD groups. Our findings align with prior UNOS based studies which also reported lower graft survival rates in SSc transplant recipients. These poorer outcomes are likely multifactorial, potentially driven by SRC recurrence and multi-organ involvement.

Survival curves comparing graft and patient survival between sclerosis and non-sclerosis cohort following kidney transplant over a 5-year period.

Digital Object Identifier (DOI)

• doi: 10.1681/ASN.2025wgqj61sm