Abstract: TH-PO1034
Descriptive Evaluation of Reproductive Hormone Changes and Sexual Function in Premenopausal Women Undergoing Kidney Transplantation
Session Information
- Women's Health and Kidney Diseases
November 06, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Women's Health and Kidney Diseases
- 2200 Women's Health and Kidney Diseases
Authors
- Arriola Montenegro, Jose J, Mayo Clinic Division of Nephrology and Hypertension, Rochester, Minnesota, United States
- Suvakov, Sonja, Mayo Clinic Minnesota, Rochester, Minnesota, United States
- Lobo, Angie S., University of Minnesota Twin Cities Division of Nephrology and Hypertension, Minneapolis, Minnesota, United States
- Felt, Melissa M., Mayo Clinic Minnesota, Rochester, Minnesota, United States
- Kattah, Andrea G., Mayo Clinic Division of Nephrology and Hypertension, Rochester, Minnesota, United States
Background
Chronic kidney disease (CKD) in premenopausal women disrupts the hypothalamic-pituitary-gonadal axis, leading to hormonal imbalances, menstrual irregularities, and sexual dysfunction. While kidney transplantation may restore endocrine function, its impact on reproductive hormones and sexual health remain understudied.
Methods
In this prospective cohort study, 14 premenopausal women were evaluated before (Visit 1) and after (Visit 2) kidney transplantation. Hormones associated with reproductive health and sexual function were checked, including testosterone, prolactin, dehydroepiandrosterone (DHEAS), and anti-mullerian hormone. Sexual function was assessed using the Female Sexual Function Index (FSFI), with scores <26.55 indicating dysfunction. General health was evaluated using the SF-36 general health domain (0-100 scale); scores >50 indicate above-average health-related quality of life.
Results
The median participant age was 31.5 years (IQR: 26.2–36.7); 42.9% were on dialysis pre-transplant, and none had diabetes. At Visit 1, no participants were using hormonal contraception; by Visit 2, 28.5% had initiated hormonal therapy and so cyclical sex hormones were not evaluated. Menstrual regularity improved post-transplant, with nearly all participants reporting regular cycles. Changes in scores and hormones are shown in Table.
Conclusion
Kidney transplantation in premenopausal women results in improved general health and consistent hormonal changes, particularly reduced prolactin levels. Despite physiological improvements, sexual dysfunction persists, highlighting the need for ongoing, integrated reproductive health care post-transplant.