Abstract: PUB063
Research on the Correlation Between Parathyroid Hormone and Prolactin in Patients on Hemodialysis
Session Information
Category: Bone and Mineral Metabolism
- 502 Bone and Mineral Metabolism: Clinical
Authors
- Cao, Changchun, Sir Run Run Hospital Nanjing Medical University, Nanjing, Jiangsu, China
- Ji, Jiming Ming, Sir Run Run Hospital Nanjing Medical University, Nanjing, Jiangsu, China
- Zhou, Zhou yufei Yufei, Nanjing Medical University, Nanjing, Jiangsu, China
- Wang, Zhaowei, Nanjing Medical University, Nanjing, Jiangsu, China
Background
Hyperprolactinemia (HPRL), a common endocrine disorder in end-stage chronic kidney disease (CKD) hemodialysis patients with hyperparathyroidism (HPTH), severely impacts quality of life and prognosis.
Methods
Clinical data of 113 CKD hemodialysis patients (45 males, 68 females; age 59.95±2.12 years; disease duration 5.07±0.71 years) from January 2021 to December 2024 were retrospectively analyzed. Patients were stratified by prolactin (PRL) levels: mild (L-HPRL: greater than 1 times normal), moderate (M-HPRL: 1–2 times), and severe (H-HPRL: greater than 3 times). Data were analyzed using SPSS 26.0.
Results
HPRL prevalence was 75.22% (85/113), higher in females (P<0.05). Patients were divided into 3 groups:L-HPRL 41 (36.28%), M-HPRL 15 (13.27%), H-HPRL 29 (25.66%). HPTH coexisted in 62.83% (71/113), most severe in L-HPRL (P<0.05). Male sexual dysfunction included erectile dysfunction (45.83%), reduced libido (33.33%), and orgasmic disorder (20.83%).
Conclusion
HPRL is prevalent in end-stage CKD hemodialysis patients, strongly associated with HPTH and sexual dysfunction, with mild HPRL showing the most pronounced parathyroid abnormalities, guiding clinical diagnosis and management.
General Information of the Subjects
| Sex |
| Men（n=45，39.82%） |
| Women(n=68,60.18%) |
| CKD Course (5.07 ± 0.71 years) |
| Age(21-87 year,59.95±2.12 year) |