Abstract: SA-PO1213
Measurement Properties of an Electronic Patient-Reported Outcome Measure Used in Nondialysis-Dependent Kidney Care
Session Information
- CKD: Biomarkers and Emerging Tools for Diagnosis and Monitoring
November 08, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2302 CKD (Non-Dialysis): Clinical, Outcomes, and Trials
Authors
- Patel, Dipal M., The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States
- Han, Dingfen, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States
- Segal, Jodi B, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States
Background
People with non-dialysis-dependent CKD (CKD-ND) face several symptoms and impairments to quality of life (QoL). We previously deployed an electronic patient-reported outcome measure (ePROM) based on the Kidney Disease Quality of Life-36 to patients with CKD-ND as part of routine nephrology care. We hypothesized that the ePROM would demonstrate validity when used in real-world care settings.
Methods
Retrospective analysis of electronic health record (EHR) data with evaluation of ePROM temporal stability (strength of association between multiple ePROM responses provided by individuals with stable kidney function), responsiveness [detection of minimal clincially important difference (MCID) in scores for individuals with declining kidney function], and convergent construct validity [strength of association between ePROM and validated Medicare Annual Wellness Visit (MAWV) assessments].
Results
The ePROM demonstrated temporal stability for 147 individauls who maintained stable kidney function (Figure 1A). Among 35 individuals who completed > 2 ePROMs within 365 days and had a significant decline in kidney function, the ePROM detected a MCID in physical symptom and mental health scores of > 3 for individuals with baseline advanced CKD-ND (Figure 1B). The ePROM demonstrated convergent construct validity with MAWV questionnaire assessments of general health, QoL, and depression (Figure 1C).
Conclusion
The ePROM demonstrated temporal stability and construct validity, and detected a MCID in scores for individuals with advanced CKD-ND who experienced worsening kidney function. Additional data is needed to confirm the validity of the ePROM as a tool to measure symptoms throughout care of individuals with CKD-ND.
ePROM (A) temporal stability, (B) responsiveness, and (C) construct validity. rs: Spearman’s rank correlation coefficient.
Funding
- Other U.S. Government Support