Abstract: TH-PO1063
Longitudinal Measures of Short Physical Performance Battery and Risk for CKD Progression and Death
Session Information
- CKD: Epidemiology, Risk Factors, and Other Conditions
November 06, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Schrauben, Sarah J., University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States
- Nair, Devika, Vanderbilt University Medical Center, Nashville, Tennessee, United States
- Brown, Rebecca T., University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States
- Shlipak, Michael, San Francisco VA Health Care System, San Francisco, California, United States
- Tangri, Navdeep, University of Manitoba, Winnipeg, Manitoba, Canada
- Hannan, Mary F., University of Illinois Chicago, Chicago, Illinois, United States
- Lash, James P., University of Illinois Chicago, Chicago, Illinois, United States
- Navaneethan, Sankar D., Baylor College of Medicine, Houston, Texas, United States
- Leonard, Mary B., Stanford University School of Medicine, Stanford, California, United States
- Chen, Jing, The University of Texas Southwestern Medical Center, Dallas, Texas, United States
- He, Jiang, The University of Texas Southwestern Medical Center, Dallas, Texas, United States
- Appel, Lawrence J., Johns Hopkins Medicine, Baltimore, Maryland, United States
- Rincon-Choles, Hernan, Cleveland Clinic, Cleveland, Ohio, United States
- Kansal, Mayank, University of Illinois Chicago, Chicago, Illinois, United States
- Yang, Wei, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States
Background
We aimed to characterize physical performance using the Short Physical Performance Battery (SPPB) and test whether physical performance is associated with incident kidney failure and death in a cohort of adults with chronic kidney disease (CKD).
Methods
Using data from the Chronic Renal Insufficiency Cohort (CRIC) Study, we calculated SPPB scores from three performance measures (standing balance, gait speed, chair stands). SPPB scores were categorized into peformance levels using validated cut-offs: low (0-6), moderate (7-9), and high (10-12). We estimated the associations of baseline SPPB and longidutinal SPPB change, modelled continuously and by performance category, with incident kidney failure and death using multivariable Cox models.
Results
Among 3,038 participants, mean age was 64 years, 40% were Black, 52% had diabetes and mean eGFR was 52 ml/min/1.73m^2. Median (IQR) follow up was 8.5 years (7-10). The baseline median (IQR) SPPB score was 10 (8-11), indicating median high performance. In fully adjusted models, lower baseline SPPB scores (per 1-unit) and low and moderate performance categories were associated with increased risk of death (Table). As a linear measure, SPPB declines were associated with higher risk of death; and a >2 point decline was associated with 78% higher mortality risk compared to no change (Table). Baseline and SPPB change were not associated with incident kidney failure.
Conclusion
Baseline physical peformance and its changes over time, as measured by the SPPB, are independently associated with death. The SPPB may be a useful tool for risk assessment in this population.
Funding
- NIDDK Support