Abstract: SA-PO1119
Temporal Trends of CKD Burden Attributable to Metabolic Risks Among Elderly Patients: Findings from the Global Burden of Disease Study 2021 Analysis
Session Information
- Geriatric Nephrology
November 08, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Geriatric Nephrology
- 1300 Geriatric Nephrology
Author
- Yang, Yaqin, Rijksuniversiteit Groningen, Groningen, GR, Netherlands
Group or Team Name
- University Medical Center Groningen.
Background
Metabolic risk factors contribute to CKD progression in aging populations, but their evolving impact remains insufficiently characterized. This study aims to assess temporal trends of chronic kidney disease (CKD) attributable to metabolic risks among the elderly population by utilizing data from the Global Burden of Disease (GBD) 2021.
Methods
Utilizing data from the GBD 2021, we estimated mortality, disability-adjusted life years (DALYs), age-standardized mortality rates (ASMR), and age-standardized DALYs rates (ASDR) of CKD burden attributable to metabolic risks among individuals aged 65 years and older. The composition of metabolic risk factors was evaluated, and the annual average percentage change (AAPC) was calculated employing the Joinpoint model to examine the evolving trajectory of metabolic-related CKD ASMR and ASDR. The age-period-cohort model was deployed to assess the effects of age, time, and cohort on CKD mortality.
Results
From 1990 to 2021, the global burden of metabolic-related CKD exhibited a general upward trend among populations over 65. High fasting plasma glucose (HFPG) emerged as the leading risk factor, while high body-mass index (HBMI) demonstrated rapid growth. Regional disparities were evident, with low Socio-Demographic Index (SDI) regions having the highest ASDR and ASMR rates, while high SDI regions also showed significant increases, as revealed by Joinpoint analysis. The burden among older populations consistently increased, with A-P-C analysis revealing notable rises in period and cohort relative risks in recent years.
Conclusion
The escalating burden of metabolic-related CKD highlights an urgent need for targeted public health strategies, suggesting the importance of targeted approaches to manage CKD across regions with different socioeconomic and healthcare profiles.
The AAPC of DALY rate for chronic kidney disease among population over 65 years old in 204 countries and territories from 1990 to 2021.
Funding
- Clinical Revenue Support