Abstract: FR-PO1097
Influence of Changing Dietary Phosphorus-to-Protein Ratio on Serum Phosphorus and the Nutritional Status in Patients on Hemodialysis
Session Information
- Health Maintenance, Nutrition, and Metabolism
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Health Maintenance, Nutrition, and Metabolism
- 1500 Health Maintenance, Nutrition, and Metabolism
Authors
- Wang, Song, Peking University Third Hospital, Beijing, China
- Tian, Xinkui, Peking University Third Hospital, Beijing, China
- Lu, Xinhong, Peking University Third Hospital, Beijing, China
- Wang, Yue, Peking University Third Hospital, Beijing, China
Background
To investigate the impact of altering dietary phosphorus-protein ratio on serum phosphorus and the nutritional status of hemodialysis patients.
Methods
A self-controlled clinical study was conducted on patients with serum phosphorus ≥1.78 mmol/L despite low-phosphorus diet education. Subjects replaced staple foods with an equal amount of low-protein rice, and the protein difference between regular rice and low-protein rice was supplemented with an equal amount of low-phosphorus whey protein. After 10 weeks of dietary intervention, changes in phosphorus, albumin, and body composition measurements were analyzed.
Results
A total of 29 patients were enrolled, with a mean age of 58.4±14.1 years. At baseline, the dietary phosphorus-protein ratio was (15.85±3.29) mg/g, serum phosphorus was (2.05±0.32) mmol/L, and serum albumin was (39.84±3.23) g/L. After 10 weeks of intervention, the dietary phosphorus-protein ratio decreased to (12.18±2.45) mg/g, serum phosphorus decreased to (1.87±0.44) mmol/L, and serum albumin increased to (42.29±3.51) g/L, with significant differences compared to baseline (p<0.001, 0.048, <0.001，respectively). Total calorie and protein intake showed no significant changes. Additionally, patients experienced an increase in dry weight (65.09±15.30 vs. 64.71±15.07 kg, p=0.030), mid-upper arm muscle circumference (22.57±2.83 vs. 22.00±3.03 cm, p=0.013), and grip strength in the non-fistula upper limb (27.89±7.82 vs. 26.54±7.90 kg, p=0.032). No significant changes were observed in subjective comprehensive assessment or lipid levels. The dialysis regimen remained unchanged throughout the study, and no adverse events occurred.
Conclusion
In hemodialysis patients, replacing regular rice with low-protein rice combined with low-phosphorus whey protein can adjust the dietary phosphorus-protein ratio while maintaining calorie and protein intake. This intervention effectively reduces serum phosphorus levels, improves serum albumin levels, and enhances muscle mass and strength.