Abstract: TH-PO0965
Ethnic Disparities in CKD Progression: Comparative Study of Two Cohorts
Session Information
- Diversity and Equity in Kidney Health
November 06, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Diversity and Equity in Kidney Health
- 900 Diversity and Equity in Kidney Health
Authors
- Jung, Hyejin, Department of Internal Medicine, Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
- Ko, Byounghwi, Department of Internal Medicine, Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
- Jung, Chan-Young, Division of Nephrology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea (the Republic of)
- Ko, Ye Eun, Department of Internal Medicine, Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
- Kang, Dong Hoon, Department of Internal Medicine, National Health Insurance Service Medical Center, Ilsan Hospital, Goyang, Korea (the Republic of)
- Heo, Ga Young, Division of Nephrology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea (the Republic of)
- Koh, Hee Byung, Department of Internal Medicine, Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
- Park, Cheol Ho, Department of Internal Medicine, Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
- Kim, Hyung Woo, Department of Internal Medicine, Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
- Park, Jung Tak, Department of Internal Medicine, Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
- Chang, Tae ik, Department of Internal Medicine, National Health Insurance Service Medical Center, Ilsan Hospital, Goyang, Korea (the Republic of)
- Yoo, Tae-Hyun, Department of Internal Medicine, Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
- Kang, Shin-Wook, Department of Internal Medicine, Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
- Park, Sue K., Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea (the Republic of)
- Jung, Ji Yong, Division of Nephrology, Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea (the Republic of)
- Jeong, Jong Cheol, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea (the Republic of)
- Kim, Yaeni, Department of Internal Medicine, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea (the Republic of)
- Oh, Kook-Hwan, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea (the Republic of)
- Anderson, Amanda Hyre, Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, United States
- Yang, Wei, Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States
- Cohen, Jordana B., Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States
- Rahman, Mahboob, Division of Nephrology and Hypertension, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio, United States
- Han, Seung Hyeok, Department of Internal Medicine, Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
Background
Ethnic differences in chronic kidney disease progression remain understudied, particularly between Asian and Western populations. Therefore, we aimed to investigate ethnic disparities in chronic kidney disease progression by comparing nationwide cohorts from South Korea (KNOW-CKD) and the United States (CRIC).
Methods
Overall, 4,953 participants were recruited. The primary outcome was chronic kidney disease progression, defined as a halving of estimated glomerular filtration rate or kidney failure with renal replacement therapy. In the secondary outcome analysis, we compared estimated glomerular filtration rate decline rates and all-cause mortality.
Results
Of the 4,953 participants, chronic kidney disease progression occurred in 1,283 and 570 in the KNOW-CKD and CRIC cohorts, with incidence rates of 67.9 and 41.7 per 1 000 person-years, respectively. The hazard ratio for the KNOW-CKD compared to CRIC was 1.71 (95% confidence interval, 1.50–1.95). The annual estimated glomerular filtration rate decline was steeper in KNOW-CKD participants than in CRIC participants (–2.51 vs. –1.14 mL/min/1.73 m2). Asians from the CRIC cohort exhibited a similar estimated glomerular filtration rate slope to those from KNOW-CKD (–2.10 mL/min/1.73 m2), while the slope was –1.47, and –0.81 mL/min/1.73 m2 for Blacks and Whites, respectively. However, the risk of mortality was significantly lower in KNOW-CKD participants compared with CRIC participants (hazard ratio, 0.53; 95% confidence interval, 0.40–0.71).
Conclusion
Chronic kidney disease progression was faster in the Korean cohort than in the US cohort, with Asians in both cohorts showing similar estimated glomerular filtration rate decline rates. However, the Korean cohort had a lower risk of mortality, indicating potential ethnic or regional differences in disease progression and survival.