Abstract: TH-PO0315
Shorter Sleep Duration Contributes to Heart Failure Risk in Type 4 Cardiorenal Syndrome
Session Information
- Hypertension and CVD: Clinical - 1
November 06, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Hypertension and CVD
- 1602 Hypertension and CVD: Clinical
Authors
- Welling, Kamryn L., University of Utah Health, Salt Lake City, Utah, United States
- Derington, Catherine G., University of Utah Health, Salt Lake City, Utah, United States
- Steiner, William Paul, University of Utah Health, Salt Lake City, Utah, United States
- Boucher, Robert E., University of Utah Health, Salt Lake City, Utah, United States
- Hartsell, Sydney Elizabeth, University of Utah Health, Salt Lake City, Utah, United States
- Sarwal, Amara, University of Utah Health, Salt Lake City, Utah, United States
- Drakos, Stavros, University of Utah Health, Salt Lake City, Utah, United States
- Beddhu, Srinivasan, University of Utah Health, Salt Lake City, Utah, United States
Background
The pathophysiology of type 4 cardio-renal syndrome in which CKD leads to heart failure (HF) is not fully elucidated. We examined whether shorter sleep duration increased the risk of HF in patients with CKD using data from the UK Biobank.
Methods
502,001 UK Biobank participants with baseline sleep questionnaire and eGFR data collected between 2006-2010 were included. Based on self-reported sleep duration, sleep duration groups were defined: < 7 hours, 7-8 hours and > 8 hours. CKD was defined as baseline eGFR < 60. Follow-up (until 10/31/22) HF hospitalizations were defined by ICD codes. Multivariate Cox models estimated the independent associations of sleep duration (ref 7-8 hrs) and CKD (ref non-CKD) on HF, testing for multiplicative interactions. We also defined six sleep-duration/CKD status groups and related them with the risk of HF with sleep duration 7-8 hrs and non-CKD as the reference group.
Results
Mean age was 57±8 years, 54% female, and 4.6% had CKD. 26.5%, 38.3% and 35.2% had average daily sleep durations of <7, 7-8 and >8 hrs, respectively. Compared to sleep duration 7-8 hr group, < 7 hrs group had higher baseline prevalence of T2D (4.2% vs. 6.4%) and CAD (3.5% vs. 5.7%). There were 17444 HF events over 6,700,000 years of follow-up. Shorter sleep duration and CKD were independent predictors of HF; compared to sleep duration 7-8 hrs, HR, 95% CI for HF with sleep duration > 8hrs and < 7 hrs and were 1.04 (1.00, 1.08) and 1.23 (1.18, 1.28); CKD had higher hazard of HF (HR 2.26, 95% CI 2.1, 2.4). A product term of sleep duration and CKD was non-significant (p = 0.51). As shown in figure, compared to those with sleep duration 7-8 hrs and non-CKD, those with both sleep duration < 7 hrs and CKD had the highest risk of HF.
Conclusion
Shorter sleep duration is a potentially modifiable risk factor for HF in CKD. Interventions to promote sleep hygiene might lower the risk of HF in CKD.