Abstract: FR-PO1094
Physical Activity Confers Greater Mortality and Longevity Benefits in Individuals with Cardiovascular-Kidney-Metabolic Conditions Than in Healthy Adults: A Cohort Study of Half a Million Participants
Session Information
- Health Maintenance, Nutrition, and Metabolism
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Health Maintenance, Nutrition, and Metabolism
- 1500 Health Maintenance, Nutrition, and Metabolism
Authors
- Tsai, Min Kuang, Taipei Medical University Shuang Ho Hospital Ministry of Health and Welfare, New Taipei City, Taiwan
- Wu, Mei-Yi, Taipei Medical University Shuang Ho Hospital Ministry of Health and Welfare, New Taipei City, Taiwan
- Wen, Chi Pang, National Health Research Institutes, Zhunan Township, Taiwan
- Wu, Mai-Szu, Taipei Medical University, Taipei City, Taiwan
Background
While the health benefits of physical activity are well established among the general health population, individuals with chronic non-communicable diseases are often advised to limit their physical activity due to perceived risks. However, the actual impact of physical activity (PA) among people with conditions like cardiovascular-kidney-metabolic (CKM) remains underexplored.
Methods
We analyzed data from 515,602 adults aged ≥20 years who participated in a screening program in Taiwan between 1996 and 2020. Participants were classified into five categories of leisure-time PA based on weekly MET-hours. Mortality outcomes were assessed through linkage with national death files. Age-standardized mortality and hazard ratios were estimated.
Results
Among participants without CKM, ≥150 minutes/week of PA was associated with a modest 2% reduction in all-cause mortality (HR: 0.98). In contrast, individuals with CKM experienced a 16% reduction (HR: 0.84), with age-standardized mortality decreasing by 64.8/100,000 person-years—1.8 times greater than in non-CKM individuals (35.7/100,000). Subgroup analyses showed that the mortality benefit of PA was especially pronounced in those with CKD (3.8-fold), diabetes (2.6-fold), hypertension (1.6-fold), metabolic syndrome (1.8-fold), and hypertriglyceridemia (1.7-fold). CKM participants meeting PA recommendations gained an 4–5 additional years of life.
Conclusion
With 5 major diseases with each different treatment modality, CKM treatment in clinical setting is complex. However, starting with PA is a powerful regimen for two reasons: First, it was highly effective for every component of CKM. Second, while exercise was known to be good for healthy people, its effect was twice as good in CKM, as it could double CKM mortality reduction. Our data underscore the importance of reminding clinicians to promote physical activity for every CKM patient.