Abstract: SA-PO0950
Changes in the Spectrum of Kidney Diseases: Analysis Based on 14,447 Kidney Biopsies from 2012 to 2023 at a Single Center in China
Session Information
- Pathology: Updates and Insights
November 08, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Pathology and Lab Medicine
- 1800 Pathology and Lab Medicine
Authors
- Qin, Ai-bo, Peking University First Hospital Department of Nephrology, Beijing, China
- Chi, Zengxin, Peking University First Hospital Department of Nephrology, Beijing, China
- Wang, Suxia, Peking University First Hospital Department of Nephrology, Beijing, China
- Zhou, Fu De, Peking University First Hospital Department of Nephrology, Beijing, China
- Zhao, Ming-Hui, Peking University First Hospital Department of Nephrology, Beijing, China
Background
To investigate the changing spectrum of kidney diseases over time in China using renal biopsy-proven cases.
Methods
All patients over the age of 14 years who were diagnosed with a kidney disease by renal biopsy in our center from 2012 to 2023 were included.
Results
In total, 14447 cases of renal biopsy were analyzed. The male-to-female ratio was 1.23:1, and the mean age was 45.0±16.2 years. Primary glomerulonephritis (PGN), secondary glomerulonephritis (SGN), tubulointerstitial disease, hereditary renal diseases, and rare and unclassified cases accounted for 64.7%, 29.2%, 3.9%, 1.8%, and 0.4%, respectively. PGN decreased significantly (p < 0.001), while SGN and tubulointerstitial disease increased (p < 0.001). Among PGN, the most frequent was IgA nephropathy (IgAN, 46.1%), followed by membranous nephropathy (MN, 37.1%), minimal change disease (MCD, 8.6%), and focal segmental glomerulosclerosis (FSGS, 4.0%). Lupus nephritis (LN, 18.5%), diabetic nephropathy (DN, 18.4%), ANCA-associated vasculitis (AAV, 12.3%), monoclonal immunoglobulin-associated renal diseases (MIg-RD, 12.2%) and hypertensive nephropathy (9.5%) were the leading SGN diagnoses. LN, Henoch- Schönlein purpura nephritis (HSPN) and hepatitis B-related nephritis (HBVN) decreased significantly (p < 0.001). While diabetic nephropathy (DN), hypertensive nephropathy and obesity related glomerulonephropathy (ORG) increased twice (p < 0.001). An analysis by age category indicated that the frequency of MIg-RD increased significantly over time (p < 0.001) in all age categories and increased by more than 5 times in the 25–44 age category.
Conclusion
PGN continued to be the predominant kidney disease in China. IgAN was still the most common PGN and followed by MN. LN and HSPN decreased significantly, while DN, HT, ORG and MIg-RD increased significantly.
Fig. 1. Temporal trends of the renal biopsy frequencies. a Frequencies of primary glomerulonephritis subtypes. b Frequencies of secondary glomerulonephritis subtypes.
Funding
- Government Support – Non-U.S.