Abstract: FR-PO1082
Association Between Level of Physical Activity and Cognition in CKD (PAC-CKD): A UK Biobank Study
Session Information
- Health Maintenance, Nutrition, and Metabolism
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Health Maintenance, Nutrition, and Metabolism
- 1500 Health Maintenance, Nutrition, and Metabolism
Authors
- Ryan, Louise A., University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom
- Dasgupta, Indranil, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom
Background
Cognitive function (CF) declines steadily with advancing CKD and affects up to 80% of people with end-stage kidney disease. Physical activity (PA) reduces the risk of cognitive impairment in the general population. We aimed to assess the association of PA with CF in adults with CKD using the UK Biobank data.
Methods
CF was assessed by a composite of fluid intelligence, numeric memory (NM) and reaction time tests. CKD was classified into stages 1-5 and "No CKD" based on eGFR and albumin creatinine ratio. PA was measured by the International Physical Activity Questionnaire and classified into high, moderate and low PA levels. Multilinear regression was performed, with the Cohen’s d, with the No CKD group as reference, reported. A Wald test was used to test the interaction of CKD stage and PA on cognitive function.
Results
Of the 501,520 participants, 692, 749, 7389, 299 and 51 had CKD stages 1-5 respectively. The median ages for no CKD and CKD stages 1 to 5 were 58, 55, 62, 65, 65, and 62 respectively. Diabetes rates were 5.4%, 23.7%, 31.4%, 21.9%, 40.8%, and 49% and hypertension rates were 26.2%, 46.1%, 68.9%, 69.3%, 83.3%, and 86.3% respectively. The percentage of participants in the high and moderate PA groups were 39.7 and 40.1 for Stage 1, 34.8 and 40.7 for Stage 2, 33.7 and 40.6 for Stage 3, 23.4 and 43.8 for Stage 4, 15.7 and 37.3 for stage 5 and 40.7 and 41.5 for those without CKD.
After adjustment for age, education and comorbidities, cognitive scores decreased with advancing CKD (table 1). Apart from NM in Stage 5 CKD, where high PA negatively affected CF, these associations did not significantly differ by PA level.
Conclusion
The decline in cognitive function with advancing CKD did not significantly differ by PA apart from NM in Stage 5, where the number was small.