Abstract: SA-PO0850
Nephrotic Syndrome with Active Pulmonary Tuberculosis: A Retrospective Study
Session Information
- Glomerular Management: Real-World Lessons and Emerging Therapies
November 08, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics
Authors
- Wen, Rui, The Affiliated Changsha Central Hospital, The University of South China, Changsha, Hunan, China
- Yang, Mingjuan, The University of South China, Hengyang, Hunan, China
- Li, Piao, The University of South China, Hengyang, Hunan, China
- Qin, Jiao, The Affiliated Changsha Central Hospital, The University of South China, Changsha, Hunan, China
Background
Nephrotic syndrome (NS) patients with active pulmonary tuberculosis (APTB) can develop life-threatening complications, including acute kidney injury and APTB diffcult to control. While little is known about NS in Adult with APTB. This study aims to describe the clinical characteristics of NS in hospitalized with APTB.
Methods
This study retrospectively reviewed NS patients (18–80 years old) with APTB admitted to our hospital from 2021.6 to 2024.6.
Results
Ninety One patients with NS and APTB were included with 25(27.47%) being female. Twenty cases of Secondary nephrotic syndrome(SNS) and APTB - Lupus nephrotic syndrome(4), Diabetic nephropathy(16), Henoch-Schonlein Purpura nephritis(1). Among the SNS and APTB, cavernous pulmonary tuberculosis(11, 52.38%) was the most commonly type except APTB. Both microbiological diagnosis and molecular diagnosis showed lower positivity rate - direat smear(33.33%), Mycobacterium tuberculosis Culture(33.33%), TB-DNA(53.85%), Xpert® MTB/RIF(53.85%).Forty Seven cases of primary nephrotic syndrome(PNS) were on GC and immunosuppressants/immunobiologics therapy at the moment APTB was diagnosed. 25 cases were complicated with more than one type of tuberculosis except APTB-tuberculous pleuris(20), Miliary Tuberculosis(9), cavernous pulmonary tuberculosis(7), extra-plumonary(21). Ten patients with NS and APTB were occur at the same time and all test showed very low positive - direat smear(0%), Mycobacterium tuberculosis Culture(10%), TB-DNA(0%), Xpert® MTB/RIF(0%). Thirteen cases of APTB were on anti-tuberculosis chemotherapy at the moment NS was diagnosed and 8 cases were considered Drug-induced SNS, including tiopronin(4), rifamycin(4). NGS has a high diagnostic positivity (16/17,94.12%）Significantly compared to the microbiological and molecular diagnostic test.
Conclusion
The clincal characteristics are very complex in NS with APTB and should be careful identificated. The positive rate of microbiological diagnosis and molecular diagnosis of these patients was low. NGS can be used to increase the diagnostic yield.
Case Composition in NS-APTB
Funding
- Clinical Revenue Support