Abstract: TH-PO1071
Higher Incidence of CKD and ESKD Among Adults with Post-Traumatic Stress Disorder (PTSD) and Major Depressive Disorder (MDD)
Session Information
- CKD: Epidemiology, Risk Factors, and Other Conditions
November 06, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Bragg-Gresham, Jennifer L., University of Michigan Medical School, Ann Arbor, Michigan, United States
- Bano, Ruqiyya, Stony Brook University, Stony Brook, New York, United States
- Han, Yun, Precision AQ, New York, New York, United States
- Pavkov, Meda E., Centers for Disease Control and Prevention, Atlanta, Georgia, United States
- Han, Sola, Centers for Disease Control and Prevention, Atlanta, Georgia, United States
- Koraishy, Farrukh M., Stony Brook University, Stony Brook, New York, United States
- Saran, Rajiv, University of Michigan Medical School, Ann Arbor, Michigan, United States
Background
Mental health disorders such as PTSD and MDD are highly prevalent among US Veterans. We hypothesize that these conditions may make people more likely to develop CKD and accelerate its progression, compared to populations who are not affected.
Methods
We assessed the association between presence of PTSD and/or MDD and risk of CKD or end-stage kidney disease (ESKD) among two cohorts. The first included data on Veterans with at least one inpatient or outpatient visit between 2010-2012, with no laboratory indication or diagnosis of CKD or ESKD during that time (N = 4,502,210). The second included ~427K individuals in the Stony Brook University TriNetX dataset, chosen on the same criteria. Incident CKD is defined by at least two laboratory measurements at least 3 months apart indicating CKD or a diagnosis of CKD. Cox models assessed the association between PTSD and/or MDD and CKD and/or ESKD, adjusted for age, sex, race/ethnicity, cardiovascular disease (CVD), diabetes, hypertension, alcohol use disorder (AUD), and smoking status. The closed cohort of Veterans was followed for 10 years (2013-2022) and closed cohort of TriNetX patients for 5 years (2017-2022). Patients without the outcome were censored at the end of the or if they left the cohort for other reasons.
Results
Veterans with MDD and/or PTSD had significantly greater rates of incident CKD or ESKD. In the TriNetX cohort, similar significant associations were seen, except for the association between PTSD and ESKD, possibly due to the shorter follow-up time. (Table)
Conclusion
Significant associations were found between PTSD and/or MDD and kidney outcomes in two large data sets. More attention needs to be paid to these debilitating mental health conditions, as not only significant health conditions themselves, but also as important risk factors for the new onset CKD and its progression to ESKD.
Funding
- Other U.S. Government Support