Abstract: SA-OR081
Living-Donor Kidney Transplantation in the Genomics Era: Insights from an International Registry
Session Information
- Transplantation: Clinical Controversies in Donation, Access, Monitoring, and Treatment
November 08, 2025 | Location: Room 370A, Convention Center
Abstract Time: 05:50 PM - 06:00 PM
Category: Transplantation
- 2102 Transplantation: Clinical
Authors
- Caliskan, Yasar, Saint Louis University, St. Louis, Missouri, United States
- Oto, Ozgur Akin, Istanbul Universitesi, Fatih, Istanbul, Turkey
- Alhamad, Tarek, Washington University in St Louis, St. Louis, Missouri, United States
- Yazici, Halil, Istanbul Yeni Yuzyil Universitesi, Istanbul, Turkey
- Velioglu, Arzu, Marmara Universitesi, Istanbul, Turkey
- Yildiz, Abdulmecit, Bursa Uludag Universitesi, Nilüfer, Bursa, Turkey
- Radunovic, Danilo, Klinicki Centar Crne Gore, Podgorica, Podgorica Municipality, Montenegro
- Garg, Neetika, University of Wisconsin-Madison, Madison, Wisconsin, United States
- Ural, Zeynep, Gazi Universitesi, Ankara, Turkey
- Mejia, Christina Irene, Johns Hopkins University, Baltimore, Maryland, United States
- Viklicky, Ondrej, Institut klinicke a experimentalni mediciny Pracoviste laboratornich metod, Prague, Czechia
- Jittirat, Arksarapuk, UH Cleveland Medical Center, Cleveland, Ohio, United States
- Ozkurt, Sultan, Eskisehir Osmangazi Universitesi, Eskisehir, Turkey
- Daloul, Reem, Allegheny General Hospital, Pittsburgh, Pennsylvania, United States
- Trujillo, Hernando, Hospital Universitario 12 de Octubre, Madrid, Community of Madrid, Spain
- Soliman, Karim, Medical University of South Carolina, Charleston, South Carolina, United States
- Turkmen, Aydin, Istanbul Universitesi, Fatih, Istanbul, Turkey
- Lee, Brian, Dell Seton Medical Center at The University of Texas, Austin, Texas, United States
- Thomas, Christie P., University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States
- Mannon, Roslyn B., University of Nebraska Medical Center, Omaha, Nebraska, United States
- Lentine, Krista L., Saint Louis University, St. Louis, Missouri, United States
Background
Genetic considerations are increasingly important in living kidney donor candidate (LKDC) evaluation, especially when LDKCs have a family history of chronic kidney disease (CKD) or are donating to related recipient candidate with suspected genetic etiologies. The LDGen registry captures global practices in LKDC evaluation to inform safer, more consistent genetic screening approaches.
Methods
We established a multicenter, cross-sectional REDCap registry to collect de-identified data on LKDCs who (1) underwent genetic testing, (2) had a family history of genetic kidney disease, or (3) were donating to a related intended recipient with CKD of unknown etiology. Participating centers were based in the U.S. and internationally. Data collection occurred between June 2023 and April 2025.
Results
1175 LKDC evaluations were captured from 17 centers, 8 from U.S. and 9 from international centers.(Table 1) The median LKDC age was 47 years, with 55.5% women. U.S. LKDCs were younger (median 39.5 vs. 48 years, p<0.001), more often unrelated to the intended recipient and more likely to be the recipient's child and less likely a parent (p=0.004 and p<0.001, respectively). Among intended recipients, 38.7% had a possible genetic kidney disease and 29.2% had CKD of unknown etiology. Common diagnoses included Alport Syndrome (24.4%), ADPKD (21.8%), FSGS (15.1%), and aHUS (11%). U.S. recipient candidates were older (median 46 vs.32 years, p<0.001), and genetic diagnoses distributions varied significantly by region (p<0.001). (Table 2)
Conclusion
This multi-center registry provides a broad view of LKDCs in genetically complex transplant evaluations. Regional differences in donor-recipient candidate demographics and genetic diagnoses highlight the need for tailored approaches to genetic screening and counseling in LKDC evaluations.