Abstract: TH-PO1073
Depressive Symptoms in a National CKD Clinical Cohort
Session Information
- CKD: Epidemiology, Risk Factors, and Other Conditions
November 06, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Wrone, Elizabeth M., West Coast Kidney Institute, Concord, California, United States
- Stedman, Margaret R., Stanford University School of Medicine, Stanford, California, United States
- Parvathinathan, Gomathy, Stanford University School of Medicine, Stanford, California, United States
- Kwon, Katherine Westin, Panoramic Health, Tempe, Arizona, United States
- Mooney, Ann, Panoramic Health, Tempe, Arizona, United States
- Eckhardt, Douglas, Panoramic Health, Tempe, Arizona, United States
- Marcus, Roy G., Panoramic Health, Tempe, Arizona, United States
- Chertow, Glenn M., Stanford University School of Medicine, Stanford, California, United States
- Brady, Brian, Stanford University School of Medicine, Stanford, California, United States
Background
Depressive symptoms are well described among patients with end-stage kidney disease (ESKD). However, much less is known about the presence and severity of depressive symptoms among patients with non-dialysis-requiring CKD.
Methods
We identified 18,889 patients across 19 states from 25 nephrology practices affiliated with Panoramic Health. We selected patients who completed depression screening with the Patient Health Questionnaire-9 (PHQ-9) the majority of whom were participants in the Comprehensive Kidney Care Contracting (CKCC) program of the US Centers of Medicare and Medicaid Services (CMS). This cross-sectional analysis examines the association between PHQ-9 score (outcome) and CKD stage (primary exposure) and includes clinical data to explore bias and heterogeneity. The CKD-EPI 2021 equation was used to calculate eGFR.
Results
The Table shows demographics, CKD and PHQ-9 categories. Depressive symptoms considered mild (PHQ-9 score 5-9), moderate (10-14), moderate to severe (15-19) and severe (20-27) were observed in 16.7%, 5.8%, 2.3%, and 0.8% of patients, respectively. The Figure shows the distribution of PHQ-9 score by CKD stages G1/2, G3a, G3b, G4, G5 (not receiving dialysis), and G5d (ESKD).
Conclusion
Depressive symptoms are relatively common in patients with non-dialysis-requiring CKD. We find the prevalence and severity of symptoms directly correlate with CKD stage and warrant further study.
Funding
- Clinical Revenue Support