Abstract: PUB237
Prevalence and Histological Patterns of Renal Involvement Among Adult Patients with Systemic Lupus Erythematosus from a Single Center in Nigeria
Session Information
Category: Glomerular Diseases
- 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics
Authors
- Adeyeye, Lawrence A., Aminu Kano Teaching Hospital, Kano, Nigeria
- Abdu, Aliyu, Aminu Kano Teaching Hospital, Kano, Nigeria
- Mustapha, Abdulrahman, Aminu Kano Teaching Hospital, Kano, Nigeria
- Nalado, Aishatu Muhammad, Aminu Kano Teaching Hospital, Kano, Nigeria
- Kofar Na'isa, Musa Bello, Aminu Kano Teaching Hospital, Kano, Nigeria
Background
Kidney involvement is a serious complication of systemic lupus erythematosus (SLE) leading to increased morbidity and mortality. Kidney involvement may present with a variety of clinical features hence kidney biopsy is important to provide a histologic diagnosis for prognostication and direct the initial therapeutic approach. Not much has been previously reported from our setting.
Methods
This is a hospital-based cross-sectional study in whch 45 patients diagnosed with SLE using Systemic Lupus International Collaborating Clinics 2012 Criteria, were screened for Lupus Nephritis (LN) using clinical assessment. Urine and blood samples were collected for urinalysis, urine sediment microscopy, albumin creatinine ratio, serum urea, electrolytes and creatinine. Participants with persistent proteinuria and albumin creatinine ratio >500mg/g and those with haematuria, red blood cell casts and/or reduced renal function without any contra indication, had a percutaneous kidney biopsy (PKB) after obtaining informed consent. The samples obtained underwent histopathological examinations involving both light microscopy and immunohistochemistry.
Results
The mean age of the participants was 28.9 ± 8.4 years and 93.3% were females. Eighteen out of the 45 SLE patients screened had LN, accounting for a prevalence of 40% (95% CI: 25.7 – 55.7%) . All the 18 had succesfull PKB and all had evidence of lupus nephritis histologically. The most prevalent class of LN was class II(38.9%), while the least was class V(5.6%). No patient had class VI LN from this study.
Conclusion
Lupus Nephritis is prevalent among adult SLE patients and the most common histology being class being Class II, a non-proliferative class of LN with a lower risk of developing end-stage renal disease (ESRD) if they are properly followed-up. There is the need for screening SLE patient for LN so as to enable early diagnosis and institution of appropriate treatment.