Abstract: FR-PO0275
Association of Metabolic Dysfunction-Associated Steatotic Liver Disease with Kidney Stone Risk in the Nurses' Health Study II
Session Information
- Bone and Mineral Metabolism: Clinical Epidemiology and Outcomes
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Bone and Mineral Metabolism
- 502 Bone and Mineral Metabolism: Clinical
Authors
- Crivelli, Joseph J., The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, United States
- Ferraro, Pietro Manuel, Universita degli Studi di Verona, Verona, Veneto, Italy
- Chan, Andrew T, Massachusetts General Hospital, Boston, Massachusetts, United States
- Curhan, Gary C., Brigham and Women's Hospital, Boston, Massachusetts, United States
- Wood, Kyle, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, United States
Background
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common liver disease in the US, affecting 32% of the US adult population. We examined the association between MASLD and incident kidney stones, adjusting for potential confounders including diet, lifestyle, and metabolic risk factors such as obesity.
Methods
Female participants of the Nurses’ Health Study II with no baseline history of kidney stones were included in this analysis. Kidney stones were reported and confirmed by questionnaire. Physician-diagnosed MASLD was reported on questionnaires completed every 2 years from 2013 to 2021, with 1995 as the earliest year of diagnosis (baseline). We used multivariable-adjusted Cox models to examine the association between MASLD and risk of incident kidney stone disease, censoring incident kidney stones within 2 years of the MASLD diagnosis to limit detection bias.
Results
A total of 84,889 participants met study criteria. During 26 years of follow-up, there were 3,195 incident kidney stones. Compared to women without a MASLD diagnosis, those with a MASLD diagnosis had statistically significantly higher kidney stone risk: multivariable-adjusted HR 1.44 (95% CI 1.21, 1.71); see Figure.
Conclusion
Among female registered nurses, MASLD was independently associated with substantially higher kidney stone risk even after adjustment for relevant potential confounders.
Hazard ratios and 95% confidence intervals for the association of MASLD with incident kidney stones. Multivariable model adjusted for age, body mass index, body mass index squared, physical activity, total fluid intake, alcohol intake, total caloric intake, Dietary Approaches to Stop Hypertension (DASH) score, menopause, hypertension, diabetes, thiazide use, and total cholesterol.
Funding
- Other NIH Support